Siegl H
J Pharmacol. 1985;16 Suppl 3:113-27.
The renal actions of co-dergocrine and its components (DH-ergocornine, DH-beta-ergokryptine, DH-alpha-ergokryptine and DH-ergocristine) were studied in conscious normotensive and spontaneously hypertensive (SH-) rats. Following p.o. and s.c. administration, co-dergocrine and its components induced dose-dependent increases in water and sodium chloride excretion in both strains. Changes in urinary excretion of potassium were small. Concomitantly, in SHR, blood pressure (BP) and heart rate (HR) were decreased. In both strains the salidiuretic activity of co-dergocrine remained relatively constant following prolonged administration. In addition in SHR basal plasma renin activity (PRA) as well as BP and HR were decreased. Experiments were also performed in order to investigate the mechanisms underlying the renal effects of co-dergocrine.
在清醒的正常血压大鼠和自发性高血压（SH-）大鼠中研究了麦角隐亭及其成分（二氢麦角柯宁碱、二氢β-麦角隐亭、二氢α-麦角隐亭和二氢麦角克立明）的肾脏作用。经口服和皮下给药后，麦角隐亭及其成分在两种品系中均引起水和氯化钠排泄呈剂量依赖性增加。钾的尿排泄变化较小。同时，在自发性高血压大鼠中，血压（BP）和心率（HR）降低。在两种品系中，长期给药后麦角隐亭的促尿钠排泄活性保持相对恒定。此外，在自发性高血压大鼠中，基础血浆肾素活性（PRA）以及血压和心率均降低。还进行了实验以研究麦角隐亭肾脏作用的潜在机制。
