Hochberg Jessica, Cairo Mitchell S
From the Departments of Pediatrics.
Cancer J. 2018 Nov/Dec;24(6):285-300. doi: 10.1097/PPO.0000000000000345.
Lymphomas in adolescents and young adults represent approximately one quarter of all cancers in this age group. Historically, adolescent and young adult cancer patients represent a unique population with diverging issues surrounding psychosocial hardships/barriers, economics, and lack of standardization of therapeutic approaches.Furthermore, the biologic differences within the adolescent and young adult population seen in various lymphoma subtypes likely play a role in overall outcomes for this group. Without an organized approach to clinical and translational research for adolescent and young adult patients within specialized treatment centers, this population may continue to experience inferior results. Here we look at the current perspectives of adolescent and young adult lymphomas with respect to disease biology, clinical characteristics, treatment, and prognosis of this unique lymphoma population.
青少年和青年淋巴瘤约占该年龄组所有癌症的四分之一。从历史上看，青少年和青年癌症患者是一个独特的群体，围绕心理社会困难/障碍、经济问题以及治疗方法缺乏标准化存在各种问题。此外，在各种淋巴瘤亚型中观察到的青少年和青年人群体内部的生物学差异可能对该群体的总体预后产生影响。如果在专门的治疗中心没有针对青少年和青年患者的临床和转化研究的有组织方法，这个群体可能会继续面临较差的治疗结果。在此，我们探讨青少年和青年淋巴瘤在疾病生物学、临床特征、治疗以及这一独特淋巴瘤群体预后方面的当前观点。
