Department of Anesthesiology, Wuhan No. 1 Hospital, Wuhan, PR China.
Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, PR China.
Medicine (Baltimore). 2023 Sep 8;102(36):e34416. doi: 10.1097/MD.0000000000034416.
We predicted that marital status may have predictive effects on young adult patients with cancer. A total of 37,028 young adult patients (20-39 years old) newly diagnosed with lymphoma by positive histology between 1988 and 2015 were collected from the Surveillance, Epidemiology, and End Results database. Patients were separated into married and unmarried groups. Multivariate regression was utilized to explore the association between marital status and overall survival, and propensity score matching and an inverse probability of treatment weighting were applied to corroborate our results. Among 37,028 eligible lymphoma patients, 12,827 married patients, and 12,827 unmarried patients, had equal propensity scores and were eventually recruited in this research. Moreover, married patients reported enhanced 10-year overall survival in the original group and the matched cohort. The multivariable Cox regression analysis revealed a vital advantageous influence of married status on overall mortality, with an adjusted hazard ratio (HR) of 0.54 (95% CI, 0.51-0.57, P < .001) and the association remained robust after propensity score matching (HR, 0.53, 95% CI 0.51-0.55, P < .001) and inverse probability of treatment weighting (HR, 0.53, 95% CI 0.51-0.56, P < .001) after adjusting for confounding factors. Marital status had predictive significance for overall survival in young adult patients with lymphoma.
我们预测婚姻状况可能对年轻成年癌症患者具有预测作用。我们从 Surveillance, Epidemiology, and End Results 数据库中收集了 1988 年至 2015 年间通过阳性组织学新诊断为淋巴瘤的 37028 名年轻成年患者（20-39 岁）。患者被分为已婚和未婚组。利用多变量回归探讨了婚姻状况与总生存之间的关联，并采用倾向评分匹配和治疗反概率加权法来证实我们的结果。在 37028 名合格的淋巴瘤患者中，有 12827 名已婚患者和 12827 名未婚患者具有相等的倾向评分，并最终被纳入本研究。此外，已婚患者在原始组和匹配队列中报告了 10 年总生存率的提高。多变量 Cox 回归分析显示，已婚状态对总死亡率有重要的有利影响，调整后的危险比（HR）为 0.54（95%CI，0.51-0.57，P<0.001），并且在倾向评分匹配后（HR，0.53，95%CI 0.51-0.55，P<0.001）和治疗反概率加权后（HR，0.53，95%CI 0.51-0.56，P<0.001），在调整混杂因素后，这种关联仍然稳健。婚姻状况对年轻成年淋巴瘤患者的总生存具有预测意义。
