Serhan C N, Samuelsson B
Hematology Division, Brigham and Women's Hospital, Boston, Mass.
Adv Exp Med Biol. 1988;229:1-14. doi: 10.1007/978-1-4757-0937-7_1.
The oxygenation of arachidonic acid and other polyunsaturated fatty acids by a wide variety of cell types results in the formation of several structurally distinct classes of biologically active compounds. These compounds include the prostaglandins, thromboxanes, leukotrienes, and other oxygenated derivatives of polyunsaturated fatty acids. A most recent addition to this family of biologically active compounds is the lipoxins (Figure 1). Leukotrienes and lipoxins are formed by mechanisms which involve initial oxygenation of free fatty acids by lipoxygenases. In general, lipoxygenase products display a wide range of actions and appear to be involved in immunity, the regulation of inflammation, and other physiological and pathophysiological processes. In this chapter we describe results of recent studies on the isolation, biosynthesis, stereochemistry and biological activities of this new series of compounds (lipoxins).
多种细胞类型对花生四烯酸和其他多不饱和脂肪酸的氧化作用会导致形成几类结构不同的生物活性化合物。这些化合物包括前列腺素、血栓素、白三烯以及多不饱和脂肪酸的其他氧化衍生物。这一类生物活性化合物中最新添加的成员是脂氧素（图1）。白三烯和脂氧素是通过脂氧合酶对游离脂肪酸进行初始氧化的机制形成的。一般来说，脂氧合酶产物具有广泛的作用，似乎参与免疫、炎症调节以及其他生理和病理生理过程。在本章中，我们描述了关于这一系列新化合物（脂氧素）的分离、生物合成、立体化学和生物活性的最新研究结果。
