Stenke L, Reizenstein P, Lindgren J A
Department of Medical Biochemistry and Biophysics, Danderyd Hospital, Sweden.
Leuk Res. 1994 Oct;18(10):727-32. doi: 10.1016/0145-2126(94)90053-1.
Leukotrienes and lipoxins are bioactive lipoxygenase products formed by leukocytes alone or in collaboration with other cells. While the physiological role of lipoxins remains to be clarified, accumulating evidence shows that leukotrienes are important mediators in asthma and inflammation. Consequently, recent clinical trials with leukotriene D4 receptor antagonists and 5-lipoxygenase inhibitors have demonstrated marked reduction of airway symptoms in asthmatic patients. In addition, both leukotrienes and lipoxins have been indicated as modulators of cell proliferation. This article reviews recent findings suggesting that these compounds may also participate in the regulation of human myelopoiesis. Such a role is conceivable since leukotrienes and lipoxins can be produced by bone marrow cells and potently modulate GM-CSF-induced myeloid stem cell proliferation.
白三烯和脂氧素是仅由白细胞或与其他细胞共同产生的生物活性脂氧合酶产物。虽然脂氧素的生理作用尚待阐明，但越来越多的证据表明白三烯是哮喘和炎症中的重要介质。因此，最近使用白三烯D4受体拮抗剂和5-脂氧合酶抑制剂的临床试验表明，哮喘患者的气道症状明显减轻。此外，白三烯和脂氧素均已被表明是细胞增殖的调节剂。本文综述了最近的研究结果，表明这些化合物可能也参与了人类骨髓生成的调节。鉴于白三烯和脂氧素可由骨髓细胞产生并有效调节GM-CSF诱导的髓样干细胞增殖，这样的作用是可以想象的。
