Injury Prevention Center, Connecticut Children's Medical Center, 282 Washington St, Hartford, CT 06106, USA; Connecticut Department of Public Health, 410 Capitol Ave, Hartford, CT 06134, USA.
Injury Prevention Center, Connecticut Children's Medical Center, 282 Washington St, Hartford, CT 06106, USA.
Drug Alcohol Depend. 2019 Jan 1;194:371-376. doi: 10.1016/j.drugalcdep.2018.11.002. Epub 2018 Nov 15.
Unintentional opioid overdose death rates have increased nearly 500% in Connecticut from 1999 to 2016, resulting in a major public health crisis. Two primary types of opioids have been implicated in these fatalities - illicit and pharmaceutical. The objective of this study is to describe the epidemiology of fatal unintentional opioid overdoses by type.
Using the National Violent Death Reporting System, rates of unintentional opioid-related overdose death in Connecticut were calculated. Demographic and contextual characteristics (e.g., substance misuse, mental health issues), and concomitant drug use (e.g., benzodiazepines, cocaine) were compared by opioid type.
In 2016, 867 victims of fatal unintentional opioid overdose were identified in Connecticut. The majority of deaths involved illicit opioids (79.6%). Overall, victims were mostly male, white, non-Hispanic, and aged 25-54 years. Victim sex, age, and contextual characteristics differed significantly according to opioid type. For illicit opioid deaths, victims were predominantly male, aged 44 and under, and more often had a history of substance misuse. In contrast, among pharmaceutical opioid deaths, the split between males and females was significantly less pronounced, victims were mostly aged 45 and over, and mental health diagnoses, a physical health problem and concomitant drug use were more prevalent.
Based on our findings, efforts to curb opioid-related overdose should be specific to opioid type. Interventions pertaining to pharmaceutical opioids should target females and older adults, whereas interventions for illicit opioid use should target younger audiences.
1999 年至 2016 年,康涅狄格州的非故意阿片类药物过量致死率上升了近 500%,这导致了一场严重的公共卫生危机。在这些死亡事件中,有两种主要类型的阿片类药物被牵涉其中——非法和制药。本研究的目的是描述按类型划分的致命性非故意阿片类药物过量的流行病学。
利用国家暴力死亡报告系统,计算了康涅狄格州非故意阿片类药物相关过量死亡的发生率。比较了不同类型阿片类药物的人口统计学和背景特征(如物质滥用、心理健康问题)以及同时使用的药物(如苯二氮䓬类、可卡因)。
2016 年,康涅狄格州确定了 867 名致命性非故意阿片类药物过量的受害者。大多数死亡涉及非法阿片类药物(79.6%)。总体而言,受害者主要是男性、白人、非西班牙裔,年龄在 25-54 岁之间。根据阿片类药物的类型,受害者的性别、年龄和背景特征存在显著差异。对于非法阿片类药物死亡,受害者主要是男性,年龄在 44 岁以下,且更多有物质滥用史。相比之下,在药物类阿片类药物死亡中,男性和女性的比例明显不那么明显,受害者主要是年龄在 45 岁及以上,且心理健康诊断、身体健康问题和同时使用的药物更为常见。
根据我们的研究结果,遏制阿片类药物相关过量的努力应该针对阿片类药物的类型。针对药物类阿片类药物的干预措施应针对女性和老年人,而针对非法阿片类药物使用的干预措施应针对年轻人群。