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天然抗肥胖剂及其在肥胖症治疗中的作用:未来趋势展望。

Natural anti-obesity agents and their therapeutic role in management of obesity: A future trend perspective.

机构信息

NMIMS, School of Pharmacy and Technology Management, Shirpur, Maharashtra, India.

NMIMS, School of Pharmacy and Technology Management, Shirpur, Maharashtra, India.

出版信息

Biomed Pharmacother. 2019 Feb;110:224-238. doi: 10.1016/j.biopha.2018.11.076. Epub 2018 Nov 24.

Abstract

In the present scenario, obesity is a challenging health problem and its prevalence along with comorbidities are on the rise around the world. According to world health organization and organisation for economic co-operation and development epidemiology reports, overweight and obesity are the fifth foremost causes of deaths globally. The increasing rate of obesity is becoming a mammoth problem which enormously affects an individual's quality of life. The conventional therapy of obesity mainly involves synthetic moieties and surgical procedures, which has many harmful side effects and chances of recurrence with severity. Hence, the Present review is a metanalysis of all the available data on the use of the plants with their biological source, active phytochemical constituents and a probable mechanism of action as natural anti-obesity agents. The metanalysis of data during the period of 2000-2018 was performed with the help of scientific data search engine National Center for Biotechnology Information (NCBI/PubMed). This data reveals the need and scope of further research in the development of new natural phytoconstituents for the management of obesity.

摘要

在当前的情况下,肥胖是一个具有挑战性的健康问题,其发病率以及合并症在全球范围内都呈上升趋势。根据世界卫生组织和经济合作与发展组织的流行病学报告,超重和肥胖是全球第五大致死原因。肥胖率的不断上升正在成为一个巨大的问题,极大地影响了个人的生活质量。肥胖的传统治疗主要涉及合成药物和手术,这些方法有许多有害的副作用,而且有严重复发的可能性。因此,本综述对所有关于植物的现有数据进行了荟萃分析,包括植物的生物来源、活性植物化学成分以及作为天然抗肥胖剂的可能作用机制。2000 年至 2018 年期间的数据荟萃分析是借助科学数据搜索引擎国家生物技术信息中心(NCBI/PubMed)进行的。这一数据揭示了需要进一步研究开发新的天然植物成分来管理肥胖症。

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