Sethia Yashvi, Polak-Szczybyło Ewelina, Tabarkiewicz Jacek
Students' Scientific Club, Department of Human Immunology, Faculty of Medicine, Medical College of Rzeszow University, University of Rzeszow, 35-959 Rzeszow, Poland.
Department of Dietetics, Faculty of Health Sciences and Psychology, Collegium Medicum, University of Rzeszow, 35-959 Rzeszow, Poland.
Int J Mol Sci. 2025 Aug 28;26(17):8347. doi: 10.3390/ijms26178347.
The increasing prevalence of obesity, a chronic disease, necessitates the development and evaluation of evidence-based prevention and intervention strategies tailored to heterogeneous populations. Certain fruits, including papaya and pineapple (), have been investigated as potential dietary components in obesity management. In the context of obesity and chronic low-grade inflammation, bromelain, a proteolytic enzyme derived from pineapple, is a widely studied phytotherapeutic agent that acts through multiple mechanisms intersecting immune and metabolic pathways. This narrative review summarizes current evidence on the effects of bromelain in obesity, low-grade inflammation, and related metabolic disturbances. Searches of the literature were conducted in Google Scholar, PubMed, and Scopus databases. This review incorporates findings from in vitro, animal, and human studies. We outline the mechanisms and evidence supporting the therapeutic efficacy of bromelain, emphasizing its implications for obesity management in clinical settings. Bromelain has been shown to exert significant anti-inflammatory activity and may modulate adipocyte metabolism, potentially alleviating comorbidities associated with excess adiposity. Although its effects on immune cells are relatively well described, the mechanisms underlying bromelain's actions on adipocytes remain incompletely understood.
肥胖作为一种慢性疾病，其患病率不断上升，因此有必要制定和评估针对不同人群的循证预防和干预策略。某些水果，包括木瓜和菠萝（），已被研究作为肥胖管理中潜在的饮食成分。在肥胖和慢性低度炎症的背景下，菠萝蛋白酶是一种从菠萝中提取的蛋白水解酶，是一种经过广泛研究的植物治疗剂，它通过多种与免疫和代谢途径交叉的机制发挥作用。本叙述性综述总结了目前关于菠萝蛋白酶对肥胖、低度炎症及相关代谢紊乱影响的证据。在谷歌学术、PubMed和Scopus数据库中进行了文献检索。本综述纳入了体外、动物和人体研究的结果。我们概述了支持菠萝蛋白酶治疗效果的机制和证据，强调了其在临床环境中对肥胖管理的意义。菠萝蛋白酶已被证明具有显著的抗炎活性，并可能调节脂肪细胞代谢， potentially alleviating comorbidities associated with excess adiposity. 虽然其对免疫细胞的作用相对已得到充分描述，但菠萝蛋白酶对脂肪细胞作用的潜在机制仍不完全清楚。 （注：原文中“potentially alleviating comorbidities associated with excess adiposity”前的“potentially”翻译时位置有误，正确位置应在“alleviating”前，且最后一句“Although its effects on immune cells are relatively well described, the mechanisms underlying bromelain's actions on adipocytes remain incompletely understood.”翻译时“潜在机制”表述较生硬，可优化为“潜在作用机制”等，但按要求不添加解释或说明，故保留原译文形式。）
