Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Invest Ophthalmol Vis Sci. 2018 Nov 1;59(14):DES64-DES70. doi: 10.1167/iovs.17-23746.
Measurement of tear film breakup time (TBUT) has become a standard diagnostic procedure in the dry eye clinic. Short TBUT-type dry eye is characterized by TBUT of less than 5 seconds and dry eye symptoms such as ocular fatigue or dryness; the importance of this type has recently been gaining prominence. Patients with this condition show no reduction in tear production and no staining of the ocular surface. The severity of symptoms is almost the same as in dry eye in which the ocular surface is stained with rose bengal or fluorescein. In addition to discomfort, patients suffer from decreased vision due to the unstable tear film, which can be attributed to the relative abnormality of the lipid layer, aqueous layer, and/or mucin layer. The diagnosis should be performed carefully on the basis of the patient's symptoms and the TBUT test, because the ocular surface appears normal and remains unstained.
泪膜破裂时间（TBUT）的测量已成为干眼症临床的标准诊断程序。短 TBUT 型干眼症的特征是 TBUT 小于 5 秒，以及眼部疲劳或干燥等干眼症症状；这种类型的重要性最近越来越受到关注。此类患者的泪液产生没有减少，也没有眼表面染色。症状的严重程度与用孟加拉玫瑰红或荧光素染色的眼表面的干眼症几乎相同。除了不适之外，由于泪膜不稳定，患者的视力下降，这可能归因于脂质层、水液层和/或粘蛋白层的相对异常。由于眼表面看起来正常且没有染色，因此应根据患者的症状和 TBUT 测试仔细进行诊断。
