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斜视手术对睑板腺、眼表参数及结膜印迹细胞学的影响。

Effect of Strabismus Surgery on Meibomian Glands, Ocular Surface Parameters, and Conjunctival Impression Cytology.

作者信息

Sabancı Şenol, Sadullahoğlu Canan, Yavuz Sibel, Küçük Mehmet Fatih, Kızıldağ Özbay Esra, Erol Muhammet Kazım, Doğan Berna

机构信息

Department of Ophthalmology, University of Health Science, Antalya Education and Research Hospital, 07100 Antalya, Turkey.

Department of Pathology, University of Health Science, Antalya Education and Research Hospital, 07100 Antalya, Turkey.

出版信息

Diagnostics (Basel). 2025 May 21;15(10):1291. doi: 10.3390/diagnostics15101291.

Abstract

: To investigate the effect of strabismus surgery on ocular surface parameters, meibomian glands, and conjunctival impression cytology. : Preoperative and postoperative (10th day, first month, and third month) tear break-up time (TBUT) tests, Schirmer 1 tests, corneal staining scores (CSS), meibomian gland (MG) loss rates, ocular surface disease index (OSDI) scores, and conjunctival impression cytology (IC) results of 30 patients who underwent strabismus surgery were compared. : Significant differences were found between preoperative TBUT test results and those evaluated on the postoperative 10th day and at the postoperative first month ( < 0.0001 for both). There were also significant differences between the preoperative and postoperative first- and third-month Schirmer 1 test results ( = 0.02 and < 0.0001, respectively). Furthermore, mean OSDI scores significantly differed between preoperative and postoperative 10th-day measurements ( < 0.0001). The mean postoperative 10th-day CSS was found to be significantly higher than the preoperative mean CSS ( < 0.0001). The stages in preoperative conjunctival IC samples were found to be significantly lower than those evaluated at all postoperative times ( < 0.0001 for all). Significant differences were observed between the preoperative lower eyelid MG loss rate and all postoperative MG loss rates ( < 0.0001 for the 10th day and first month and < 0.001 for the third month). Lastly, the preoperative upper eyelid MG loss rate significantly differed from all postoperative MG loss rates ( < 0.0001 for the 10th day, < 0.003 for the first month, and < 0.0001 for the third month). : We observed changes indicative of dry eye in the mean OSDI score, TBUT, Schirmer 1 test, MG loss rates, and conjunctival IC findings up to the postoperative third month in patients who underwent strabismus surgery. Therefore, we believe that patients undergoing strabismus surgery should be followed up for ocular surface diseases, particularly dry eye.

摘要

目的

探讨斜视手术对眼表参数、睑板腺及结膜印迹细胞学的影响。

方法

比较30例行斜视手术患者术前及术后第10天、第1个月和第3个月的泪膜破裂时间(TBUT)、Schirmer Ⅰ试验、角膜染色评分(CSS)、睑板腺(MG)丢失率、眼表疾病指数(OSDI)评分及结膜印迹细胞学(IC)结果。

结果

术前TBUT试验结果与术后第10天及术后第1个月评估结果之间存在显著差异(两者均P<0.0001)。术前与术后第1个月和第3个月的Schirmer Ⅰ试验结果也存在显著差异(分别为P = 0.02和P<0.0001)。此外,术前与术后第10天的平均OSDI评分存在显著差异(P<0.0001)。术后第10天的平均CSS显著高于术前平均CSS(P<0.0001)。术前结膜IC样本的分期显著低于所有术后时间点评估的分期(所有均P<0.0001)。术前下睑MG丢失率与所有术后MG丢失率之间存在显著差异(术后第10天和第1个月P<0.0001,术后第3个月P<0.001)。最后,术前上睑MG丢失率与所有术后MG丢失率存在显著差异(术后第10天P<0.0001,术后第1个月P<0.003,术后第3个月P<0.0001)。

结论

我们观察到斜视手术患者直至术后第3个月,平均OSDI评分、TBUT、Schirmer Ⅰ试验、MG丢失率及结膜IC结果出现了干眼相关变化。因此,我们认为斜视手术患者应随访眼表疾病,尤其是干眼。

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