Keio University School of Medicine, Department of Ophthalmology, Tokyo, Japan.
Invest Ophthalmol Vis Sci. 2018 Nov 1;59(14):DES163-DES168. doi: 10.1167/iovs.17-23402.
Reactive oxygen species (ROS) are produced as a by-product during the mitochondrial respiration of the oxygen and potentially able to damage the tissues. Oxidative stress occurs as a result of the disruption of the balance between the anti-oxidant system and the pro-oxidant system found in cells. It has been accepted that overexpression of ROS can be induced in the ocular surface as a result of many acute and chronic diseases and even in normal aging. Recent studies demonstrated that oxidative stress damages the ocular surface and plays an important role in the mechanism of dry eye disease. There is a need to investigate the therapeutic modalities employing topical/systemic use of antioxidants in dry eye disease. This review will summarize the recent studies showing the important relationship between oxidative stress and dry eye disease.
活性氧（ROS）是在细胞的线粒体呼吸过程中产生的氧气的副产品，并且可能会对组织造成损害。氧化应激是由于细胞中抗氧化系统和促氧化剂系统之间的平衡被打破而产生的。已经接受的是，由于许多急性和慢性疾病甚至在正常衰老过程中，ROS 的过度表达都可能在眼表面诱导。最近的研究表明，氧化应激会损害眼表面，并在干眼症的发病机制中起重要作用。有必要研究通过局部/全身使用抗氧化剂治疗干眼症的治疗方式。本综述将总结最近的研究，这些研究表明氧化应激与干眼症之间存在重要关系。
