干燥综合征、蒸发过强型和泪液分泌不足型干眼患者眼表、眼睑及眶周区域温度与正常人的比较。
Temperatures of the Ocular Surface, Lid, and Periorbital Regions of Sjögren's, Evaporative, and Aqueous-Deficient Dry Eyes Relative to Normals.
作者信息
Abreau Kerstin, Callan Christine, Kottaiyan Ranjini, Zhang Aizhong, Yoon Geunyoung, Aquavella James V, Zavislan James, Hindman Holly B
机构信息
The Flaum Eye Institute, University of Rochester, Rochester, NY, USA; Center for Visual Science, University of Rochester, Rochester, NY, USA.
The Flaum Eye Institute, University of Rochester, Rochester, NY, USA; The Institute of Optics, University of Rochester, Rochester, NY, USA.
出版信息
Ocul Surf. 2016 Jan;14(1):64-73. doi: 10.1016/j.jtos.2015.09.001. Epub 2015 Oct 23.
PURPOSE
To compare the temperatures of the ocular surface, eyelid, and periorbital skin in normal eyes with Sjögren's syndrome (SS) eyes, evaporative dry eyes (EDE), and aqueous deficient dry eyes (ADDE).
METHODS
10 eyes were analyzed in each age-matched group (normal, SS, EDE, and ADDE). A noninvasive infrared thermal camera captured two-dimensional images in three regions of interest (ROI) in each of three areas: the ocular surface, the upper eyelid, and the periorbital skin within a controlled environmental chamber. Mean temperatures in each ROI were calculated from the videos. Ocular surface time-segmented cooling rates were calculated over a 5-s blink interval.
RESULTS
Relative to normal eyes, dry eyes had lower initial central OSTs (SS -0.71°C, EDE -0.55°C, ADDE -0.95°C, KW P<.0001) and lower central upper lid temperatures (SS -0.24°C, ADDE -0.51°C, and EDE -0.54°C, KW P<.0001). ADDE eyes had the lowest initial central OST (P<.0001), while EDE eyes had the lowest central lid temperature and lower periorbital temperatures (P<.0001). Over the 5-s interblink interval, the greatest rate of temperature loss occurred following eyelid opening, but varied by group (normals -0.52, SS -0.73, EDE -0.63, and ADDE -0.75°C/s). The ADDE group also had the most substantial heat loss over the 5-s interblink interval (-0.97°C).
CONCLUSIONS
Differences in OST may be related to thermal differences in lids and periorbita along with an altered tear film. Thermography of the ocular surface, lids, and surrounding tissues may help to differentiate between different etiologies of dry eye.
目的
比较正常眼与干燥综合征（SS）眼、蒸发过强型干眼（EDE）和水样液缺乏型干眼（ADDE）的眼表、眼睑及眶周皮肤温度。
方法
对各年龄匹配组（正常、SS、EDE和ADDE）的10只眼睛进行分析。在可控环境舱内，使用非侵入式红外热像仪在三个区域的三个感兴趣区域（ROI）中获取二维图像，这三个区域分别为眼表、上睑和眶周皮肤。从视频中计算每个ROI的平均温度。在5秒的眨眼间隔内计算眼表时间分段冷却速率。
结果
与正常眼相比，干眼的初始中央眼表温度较低（SS为-0.71°C，EDE为-0.55°C，ADDE为-0.95°C，KW检验P<0.0001），中央上睑温度也较低（SS为-0.24°C，ADDE为-0.51°C，EDE为-0.54°C，KW检验P<0.0001）。ADDE组的初始中央眼表温度最低（P<0.0001），而EDE组的中央睑温度最低，眶周温度也较低（P<0.0001）。在5秒的眨眼间隔内，睁眼后温度下降速率最大，但各组有所不同（正常组为-0.52，SS组为-0.73，EDE组为-0.63，ADDE组为-0.75°C/s）。ADDE组在5秒的眨眼间隔内热量损失也最大（-0.97°C）。
结论
眼表温度差异可能与眼睑和眶周的热差异以及泪膜改变有关。眼表、眼睑及周围组织的热成像可能有助于区分干眼的不同病因。
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