Tsao Yu-Ting, Chen Hung-Chi, Hsueh Yi-Jen, Cheng Yu-Chun, Kang Eugene Yu-Chuan, Huang Chu-Yen, Lee Yung-Sung
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Department of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Transl Vis Sci Technol. 2025 May 1;14(5):7. doi: 10.1167/tvst.14.5.7.
To investigate the correlations between aqueous humor total antioxidant capacity (TAC) and glaucoma subtypes, intraocular pressure (IOP), and glaucoma medications.
This was a prospective case-control study that included 303 patients who underwent cataract surgery between April 2019 and September 2024. The participants were categorized into primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG), neovascular glaucoma (NVG), uveitic glaucoma (UG), and control groups. Aqueous humor samples were collected at the onset of surgery, and TAC and ascorbic acid (AA) levels were measured.
Significant differences in TAC levels were observed among glaucoma subtypes, with UG showing the highest levels, followed by POAG, PACG, and NVG (P < 0.001). Multivariate linear regression further revealed that TAC levels were significantly associated with maximal IOP history (β = -0.013; 95% confidence intervals [CI], -0.023 to -0.002; P = 0.017) and IOP fluctuations (β = -0.016; 95% CI, -0.027 to -0.004; P = 0.007). However, no correlation was found between TAC levels and glaucoma medications; therefore, TAC may play a role in glaucoma pathophysiology and may serve as a potential therapeutic target.
Glaucoma subtype and IOP dynamics significantly influenced the TAC levels of aqueous humor. Future research could target antioxidant therapies for patients with low TAC, particularly those with PACG, NVG, or a history of elevated or fluctuating IOP.
This study highlights the significant variation in TAC among glaucoma subtypes and its association with fluctuating IOP and thus contributes to a deeper understanding of glaucoma pathogenesis and provides information for future therapeutic research.
探讨房水总抗氧化能力（TAC）与青光眼亚型、眼压（IOP）及青光眼药物治疗之间的相关性。
这是一项前瞻性病例对照研究，纳入了2019年4月至2024年9月期间接受白内障手术的303例患者。参与者被分为原发性开角型青光眼（POAG）、原发性闭角型青光眼（PACG）、新生血管性青光眼（NVG）、葡萄膜炎性青光眼（UG）和对照组。在手术开始时采集房水样本，并测量TAC和抗坏血酸（AA）水平。
在青光眼亚型之间观察到TAC水平存在显著差异，UG的TAC水平最高，其次是POAG、PACG和NVG（P < 0.001）。多变量线性回归进一步显示，TAC水平与最高眼压病史显著相关（β = -0.013；95%置信区间[CI]，-0.023至-0.002；P = 0.017）以及眼压波动相关（β = -0.016；95%CI，-0.027至-0.004；P = 0.007）。然而，未发现TAC水平与青光眼药物治疗之间存在相关性；因此，TAC可能在青光眼病理生理学中起作用，并可能作为潜在的治疗靶点。
青光眼亚型和眼压动态变化显著影响房水的TAC水平。未来的研究可以针对TAC水平较低的患者，特别是那些患有PACG、NVG或有眼压升高或波动病史的患者进行抗氧化治疗。
本研究强调了青光眼亚型之间TAC的显著差异及其与眼压波动的关联，从而有助于更深入地理解青光眼发病机制，并为未来的治疗研究提供信息。
