Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Genome Med. 2018 Nov 27;10(1):89. doi: 10.1186/s13073-018-0596-4.
Telomere crisis is linked with many of the genomic alterations found in cancer genomes. A new understanding of how these alterations arise points towards an active role for innate immune sensors during crisis and to new opportunities for the treatment and diagnosis of cancer.
端粒危机与癌症基因组中发现的许多基因组改变有关。对这些改变如何发生的新认识表明，固有免疫传感器在危机期间发挥着积极作用，并为癌症的治疗和诊断提供了新的机会。
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