核壳结构 ZnO@m-SiO 的合成及其在牙科树脂复合材料中的增强和抗菌性能。

Synthesis of core-shell structured ZnO@m-SiO with excellent reinforcing effect and antimicrobial activity for dental resin composites.

机构信息

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Material Science and Engineering, Donghua University, Shanghai 201620, China.

出版信息

Dent Mater. 2018 Dec;34(12):1846-1855. doi: 10.1016/j.dental.2018.10.002. Epub 2018 Oct 25.

DOI:10.1016/j.dental.2018.10.002

PMID:30482610

Abstract

OBJECTIVE

The aim of this study is to explore the reinforcing effect and the antimicrobial activity of the core-mesoporous shell structured ZnO@m-SiO, which possesses the micromechanical resin matrix/filler interlocking in dental composites, and to investigate the effect of filler compositions on their physical-mechanical properties.

METHODS

ZnO@m-SiO was synthesized by a simple self-assembly method and then characterized by electron microscopy, X-ray diffraction (XRD) and N adsorption/desorption measurements. Mechanical properties of dental composites reinforced with ZnO@m-SiO and nonporous SiO particles were measured with a universal mechanical testing machine. Fracture morphologies of these composites were observed by field-emission scanning electron microscopy (FE-SEM), and their antimicrobial activities were evaluated according to the ASTM E 2180-07 (2012) method. Resin composites containing unimodal silanized SiO were served as the control group.

RESULTS

The impregnation of lower loading of ZnO@m-SiO (≤7wt%) into dental composites including silanized SiO substantially increased their mechanical properties. Among all composites, the optimal composite ZS (ZnO@m-SiO: silanized SiO=7:63, wt/wt, total filler loading 70wt%) demonstrated the best flexural strength, flexural modulus and compression strength, which were increased by 121.2, 67.1 and 32.5%, respectively, in comparison with the control composite ZS. In addition, this optimal composite also exhibited superior antimicrobial activity (>99.9%) and acceptable degree of conversion, polymerization shrinkage and curing depth.

SIGNIFICANCE

The incorporation of ZnO@m-SiO and silanized SiO as bimodal fillers led to the design and formulation of dental composites with excellent comprehensive performance, especially the improved mechanical properties and the superior antimicrobial activity.

摘要

目的

本研究旨在探讨具有微机械树脂基质/填料互锁作用的核-介孔壳结构 ZnO@m-SiO 的增强效果和抗菌活性，并研究填料成分对其物理机械性能的影响。

方法

采用简单的自组装法合成 ZnO@m-SiO，通过电子显微镜、X 射线衍射（XRD）和 N 吸附/脱附测量对其进行表征。用万能试验机测量牙科复合材料中 ZnO@m-SiO 和无孔 SiO 颗粒增强后的力学性能。用场发射扫描电子显微镜（FE-SEM）观察这些复合材料的断裂形貌，并根据 ASTM E 2180-07（2012）方法评估其抗菌活性。含有单模态硅烷化 SiO 的树脂复合材料作为对照组。

结果

将较低负载量的 ZnO@m-SiO（≤7wt%）浸渍到包括硅烷化 SiO 的牙科复合材料中，可显著提高其力学性能。在所有复合材料中，最佳复合材料 ZS（ZnO@m-SiO：硅烷化 SiO=7：63，wt/wt，总填料负载量 70wt%）的抗弯强度、抗弯模量和压缩强度分别提高了 121.2%、67.1%和 32.5%，与对照组复合材料 ZS 相比。此外，这种最佳复合材料还表现出优异的抗菌活性（>99.9%）和可接受的转化率、聚合收缩率和固化深度。