Favreau L V, Schenkman J B
Department of Pharmacology, University of Connecticut Health Center, Farmington 06032.
Biochem Pharmacol. 1988 Sep 15;37(18):3505-9. doi: 10.1016/0006-2952(88)90703-4.
The hepatic content of two individual cytochrome P-450 enzymes was analyzed in spontaneously diabetic (BB/Wor) male rats. The major male-specific form, RLM5, was found to be slightly decreased in livers of male rats shortly after the onset of diabetes. In contrast, the level of RLM6 was elevated in livers of diabetic rats that had not received insulin and had become ketotic. These results confirm that the changes in some individual forms of cytochrome P-450 after chemical (streptozotocin) induction of diabetes are also seen in the spontaneously diabetic animal. The earlier observed alterations in cytochrome P-450 are therefore due to the state of diabetes and not to inductive or depressive effects of streptozotocin.
分析了自发性糖尿病（BB/Wor）雄性大鼠肝脏中两种细胞色素P-450酶的含量。主要的雄性特异性形式RLM5在糖尿病发病后不久的雄性大鼠肝脏中略有下降。相比之下，未接受胰岛素且已出现酮症的糖尿病大鼠肝脏中RLM6的水平升高。这些结果证实，在化学（链脲佐菌素）诱导糖尿病后某些细胞色素P-450个体形式的变化在自发性糖尿病动物中也可见。因此，早期观察到的细胞色素P-450变化是由于糖尿病状态，而非链脲佐菌素的诱导或抑制作用。
