Miodovnik M, Mimouni F, Siddiqi T A, Tsang R C
Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Ohio.
Am J Perinatol. 1988 Oct;5(4):368-73. doi: 10.1055/s-2007-999724.
The rate of clinically apparent spontaneous abortions in insulin-dependent diabetic pregnancies has been prospectively determined to be twice as frequent as for the general population (29.5% versus 10 to 15%). In a series of several successive studies, we have shown that spontaneous abortions are associated with poor metabolic control around conception and/or in the early weeks of pregnancy, but not in the 1 to 2 weeks preceding the abortive event itself. There is also a significant relationship between decreased maternal magnesium status (as assessed by maternal serum magnesium concentration) and adverse fetal outcome (spontaneous abortion and/or major congenital malformations) in insulin-dependent diabetic women. We speculate that improvement of glycemic control and of magnesium status before conception and in the very early phases of organogenesis might improve embryonic and fetal survival.
胰岛素依赖型糖尿病孕妇临床明显自然流产的发生率经前瞻性研究确定为普通人群的两倍（29.5% 对比10%至15%）。在一系列连续的研究中，我们已经表明自然流产与受孕前后和/或妊娠早期的代谢控制不佳有关，但与流产事件本身前的1至2周无关。胰岛素依赖型糖尿病女性的母体镁水平降低（通过母体血清镁浓度评估）与不良胎儿结局（自然流产和/或严重先天性畸形）之间也存在显著关系。我们推测，在受孕前和器官形成的早期阶段改善血糖控制和镁水平可能会提高胚胎和胎儿的存活率。
