Siddiqi T, Rosenn B, Mimouni F, Khoury J, Miodovnik M
Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Ohio.
Obstet Gynecol. 1991 Apr;77(4):514-9.
Insulin-dependent diabetic patients are at increased risk for hypertensive disorders of pregnancy. This study was designed to study prospectively the rate of pregnancy-induced hypertension (PIH) in 175 insulin-dependent diabetic pregnancies (88 White classes B-C, 87 classes D-RT). Pregnancy-induced hypertension was defined as two or more occurrences after 20 weeks' gestation of a mean arterial pressure (MAP) of 105 mmHg or greater or an increase of 20 mmHg or greater from the baseline MAP. The rate of PIH in the diabetic population was 15.4% and was significantly associated with nulliparity, poor glycemic control in the first and second trimesters, and advanced White class. Neonatal outcome was not significantly altered in the presence of PIH. We speculate that improved glycemic control throughout pregnancy might reduce the rate of this complication in diabetic patients.
胰岛素依赖型糖尿病患者妊娠期间发生高血压疾病的风险增加。本研究旨在前瞻性地研究175例胰岛素依赖型糖尿病孕妇（88例White B-C级，87例D-RT级）的妊娠高血压（PIH）发生率。妊娠高血压定义为妊娠20周后平均动脉压（MAP）≥105 mmHg出现两次或更多次，或较基线MAP升高20 mmHg或更多。糖尿病患者中PIH的发生率为15.4%，且与初产、孕早期和孕中期血糖控制不佳以及White分级较高显著相关。PIH的存在并未显著改变新生儿结局。我们推测，整个孕期改善血糖控制可能会降低糖尿病患者这种并发症的发生率。
