Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.
Center for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Nat Cell Biol. 2018 Dec;20(12):1338-1348. doi: 10.1038/s41556-018-0235-8. Epub 2018 Nov 26.
Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for cellular homeostasis and adaption to stress. Accumulating evidence indicates that autophagy declines with age and that impaired autophagy predisposes individuals to age-related diseases, whereas interventions that stimulate autophagy often promote longevity. In this Review, we examine how the autophagy pathway restricts cellular damage and degeneration, and the impact of these functions towards tissue health and organismal lifespan.
自噬（自噬）是一种保守的溶酶体降解过程，对细胞内稳态和应激适应至关重要。越来越多的证据表明，自噬随年龄增长而下降，而自噬受损使个体易患与年龄相关的疾病，而刺激自噬的干预措施通常可促进长寿。在这篇综述中，我们研究了自噬途径如何限制细胞损伤和退化，以及这些功能对组织健康和机体寿命的影响。
