Ahmed Mohamed
Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Badrachin, 12918, Egypt.
Immun Ageing. 2025 Jul 3;22(1):28. doi: 10.1186/s12979-025-00522-y.
Aging is a multifactorial biological process driven by oxidative stress, chronic inflammation, genomic instability, and mitochondrial dysfunction. Recent research underscores the potential of naturally derived compounds to modulate these aging hallmarks. Curcumin, epigallocatechin gallate (EGCG), thymoquinone, and resveratrol exhibit antioxidant, anti-inflammatory, and autophagy-enhancing effects that target core pathways involved in cellular senescence and tissue degeneration. These phytochemicals regulate key molecular players such as sirtuins, AMPK, NF-κB, and mTOR, offering promise in delaying age-associated pathologies and promoting longevity. This review discusses the molecular mechanisms underlying their anti-aging actions and highlights their potential as dietary geroprotective interventions.
衰老 是一个由氧化应激、慢性炎症、基因组不稳定和线粒体功能障碍驱动的多因素生物学过程。最近的研究强调了天然衍生化合物调节这些衰老标志的潜力。姜黄素、表没食子儿茶素没食子酸酯（EGCG）、百里醌和白藜芦醇具有抗氧化、抗炎和增强自噬的作用，这些作用针对参与细胞衰老和组织退化的核心途径。这些植物化学物质调节关键分子，如沉默调节蛋白、AMPK、NF-κB和mTOR，有望延缓与年龄相关的病理变化并促进长寿。本综述讨论了它们抗衰老作用的分子机制，并强调了它们作为饮食性老年保护干预措施的潜力。
