标准化乙醇提取物对高脂饮食/链脲佐菌素诱导的糖尿病小鼠和大鼠的降血糖作用。
Hypoglycemic effect of standardized ethanol extract in high-fat diet/streptozotocin-induced diabetic mice and rats.
作者信息
Kim Yang-Ji, Kim Hyun-Kyu, Lee Hak Sung
机构信息
Food Science R&D Center, KolmarBNH Co., Ltd., Sejong, 30003 Korea.
出版信息
Food Sci Biotechnol. 2018 May 26;27(6):1771-1779. doi: 10.1007/s10068-018-0399-9. eCollection 2018 Dec.
Abstract
(CZ) is a perennial herb belonging to the family. CZ is used medicinally to treat inflammatory and uterine diseases in Asia. CZ was extracted with 50% ethanol and CZ extract (CZE; at 125, 250, and 500 mg/kg body weight) was administered orally every day for 5 or 6 weeks to investigate the anti-diabetic effects in streptozotocin (STZ)-induced rats and STZ + high-fat diet (HFD)-fed mice. CZE significantly decreased fasting blood glucose levels in STZ- and STZ + HFD-induced diabetic models. In addition, glucose tolerance and insulin tolerance were improved in the STZ + HFD + CZE group by increasing insulin levels and decreasing hemoglobin A1c (HbA1c) levels in serum. Furthermore, CZE supplements decreased components of the serum lipid profile such as triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels. These results suggest that CZE may be a potential candidate for controlling hyperglycemia.
摘要
(CZ)是一种属于该科的多年生草本植物。在亚洲，CZ被用于药用治疗炎症和子宫疾病。用50%乙醇提取CZ，并将CZ提取物（CZE；体重分别为125、250和500毫克/千克）每天口服给药5或6周，以研究其对链脲佐菌素（STZ）诱导的大鼠和STZ+高脂饮食（HFD）喂养的小鼠的抗糖尿病作用。CZE显著降低了STZ和STZ+HFD诱导的糖尿病模型的空腹血糖水平。此外，通过提高胰岛素水平和降低血清中糖化血红蛋白（HbA1c）水平，STZ+HFD+CZE组的葡萄糖耐量和胰岛素耐量得到改善。此外，CZE补充剂降低了血清脂质谱的成分，如甘油三酯、总胆固醇和低密度脂蛋白胆固醇水平。这些结果表明，CZE可能是控制高血糖的潜在候选药物。
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本文引用的文献
1
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Int J Mol Med. 2016 Apr;37(4):901-10. doi: 10.3892/ijmm.2016.2490. Epub 2016 Feb 18.
2
Protective effect of linarin against D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure.连翘酯苷对D-氨基半乳糖和脂多糖诱导的暴发性肝衰竭的保护作用。
Eur J Pharmacol. 2014 Sep 5;738:66-73. doi: 10.1016/j.ejphar.2014.05.024. Epub 2014 May 27.
3
Evaluation of antioxidant activity of chrysanthemum extracts and tea beverages by gold nanoparticles-based assay.基于金纳米粒子法评价菊花提取物和茶饮料的抗氧化活性。
Colloids Surf B Biointerfaces. 2012 Apr 1;92:348-52. doi: 10.1016/j.colsurfb.2011.12.007. Epub 2011 Dec 20.
4
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Br J Nutr. 2011 Dec;106(11):1713-23. doi: 10.1017/S000711451100225X. Epub 2011 Jun 21.
5
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J Ethnopharmacol. 2011 Sep 1;137(1):662-8. doi: 10.1016/j.jep.2011.06.018. Epub 2011 Jun 28.
6
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7
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J Plant Physiol. 2011 May 1;168(7):687-93. doi: 10.1016/j.jplph.2010.10.009. Epub 2010 Dec 8.
8
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Nutr Res Pract. 2010 Apr;4(2):93-8. doi: 10.4162/nrp.2010.4.2.93. Epub 2010 Apr 28.
9
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World J Gastroenterol. 2009 Apr 14;15(14):1730-7. doi: 10.3748/wjg.15.1730.
10
Antimicrobial activities of four Tunisian Chrysanthemum species.四种突尼斯菊花品种的抗菌活性。
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