柑橘类混合饮料（CBMDs）对氧化应激和束缚应激的保护作用。
Protective effects of citrus based mixture drinks (CBMDs) on oxidative stress and restraint stress.
作者信息
Cho MyoungLae, Kim Dan-Bi, Shin Gi-Hae, Kim Jae-Min, Seo Yoonhee, Choe Soo Young, Cho Ju Hyun, Kim Young-Cheul, Lee Jin-Ha, Lee Ok-Hwan
机构信息
1National Development Institute of Korean Medicine, Gyeongsan, 38540 Republic of Korea.
2Korea Food Research Institute, Wanju, 55365 Republic of Korea.
出版信息
Food Sci Biotechnol. 2018 May 23;27(6):1801-1809. doi: 10.1007/s10068-018-0396-z. eCollection 2018 Dec.
In the current study investigated the protective effects of citrus based mixture drinks (CBMDs) using oxidative stress in human dermal fibroblast (HDF) cells and restraint-stressed rats. The CBMDs contained citrus bioflavonoids including narirutin and hesperidin. The cell viability of HDF cells treated with HO was observed at 53.9% but treated with CBMD-1 and CBMD-2 (500 μg/mL) on HO exposed HDF cells significantly increased the relative cell viability at 65.0 and 72.2%, respectively. In the treadmill test, the time spent on the electrode plate in the restraint-stressed group was analyzed 24.1 s, but restraint-stressed rats with administered CBMDs (300 mg/kg) had significantly decreased the time at 2.4 (CBMD-1) and 4.7 (CBMD-2) s, respectively. In addition, number of touches the electrode plate in restraint-stressed group was observed at 42.4 ea, but, restraint-stressed rats with administered CBMD-1 and CBMD-2 (300 mg/kg) were significantly decreased at 7.0 and 10.2 ea, respectively.
在当前研究中，使用氧化应激在人皮肤成纤维细胞（HDF）和束缚应激大鼠中研究了柑橘基混合饮料（CBMDs）的保护作用。CBMDs含有柑橘生物类黄酮，包括柚皮芸香苷和橙皮苷。用HO处理的HDF细胞的细胞活力观察为53.9%，但用CBMD-1和CBMD-2（500μg/mL）处理HO暴露的HDF细胞，相对细胞活力分别显著增加至65.0%和72.2%。在跑步机试验中，束缚应激组在电极板上花费的时间分析为24.1秒，但给予CBMDs（300mg/kg）的束缚应激大鼠分别显著减少至2.（CBMD-1）和4.7（CBMD-2）秒。此外，束缚应激组触碰电极板的次数观察为42.4次，但给予CBMD-1和CBMD-2（300mg/kg）的束缚应激大鼠分别显著减少至7.0次和10.2次。
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