Marshall G D, Thurman G B, Foster B G, Goldstein A
Immunol Commun. 1977;6(6):603-15. doi: 10.3109/08820137709093470.
The effects of Moloney Sarcoma Virus (MSV) induced tumor growth dynamics on the blastogenic responsiveness of lymphocytes from BALB/c mice were investigated. Lymphocytes from spleen, thymus and lymph node pools were tested for responsiveness to phytohemagglutinin (PHA) and concanavalin A (Con A). Results showed a significant decrease in PHA-induced blastogenesis of all lymphocytes tested at the time of maximal tumor volume, with a return to normal responsiveness as the tumor regressed. In contrast, a differential dose dependent Con A response occurred in spleen and thymus lymphocytes. A decreased 3H-thymidine uptake occurred at optimal Con A dose, correlating with the PHA decrease. However, at a lower Con A dose an increased response was observed, beginning shortly before the PHA depression and continuing until regression of tumor began. This phenomena was not observed in lymph node lymphocytes. Based upon these observations, we suggest that the cell or cells responsible for the transient suppression of PHA responsiveness may be Con A responsive T lymphocytes.
研究了莫洛尼肉瘤病毒（MSV）诱导的肿瘤生长动力学对BALB/c小鼠淋巴细胞增殖反应性的影响。检测了来自脾脏、胸腺和淋巴结库的淋巴细胞对植物血凝素（PHA）和刀豆蛋白A（Con A）的反应性。结果显示，在肿瘤体积最大时，所有检测的淋巴细胞的PHA诱导增殖均显著降低，随着肿瘤消退，反应性恢复正常。相比之下，脾脏和胸腺淋巴细胞对Con A的反应存在剂量依赖性差异。在最佳Con A剂量下，3H-胸腺嘧啶核苷摄取减少，与PHA降低相关。然而，在较低的Con A剂量下，在PHA抑制前不久开始观察到反应增加，并持续到肿瘤开始消退。在淋巴结淋巴细胞中未观察到这种现象。基于这些观察结果，我们认为负责PHA反应性短暂抑制的一个或多个细胞可能是对Con A有反应的T淋巴细胞。
