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代谢在肝星状细胞激活和纤维化形成中的作用。

Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis.

作者信息

Hou Wei, Syn Wing-Kin

机构信息

Tianjin Second People's Hospital and Tianjin Institute of Hepatology, Tianjin, China.

Division of Gastroenterology and Hepatology, Department of Medicine, Medical University of South Carolina, Charleston, SC, United States.

出版信息

Front Cell Dev Biol. 2018 Nov 12;6:150. doi: 10.3389/fcell.2018.00150. eCollection 2018.

DOI:10.3389/fcell.2018.00150
PMID:30483502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6240744/
Abstract

Activation of hepatic stellate cell (HSC) involves the transition from a quiescent to a proliferative, migratory, and fibrogenic phenotype (i.e., myofibroblast), which is characteristic of liver fibrogenesis. Multiple cellular and molecular signals which contribute to HSC activation have been identified. This review specially focuses on the metabolic changes which impact on HSC activation and fibrogenesis.

摘要

肝星状细胞（HSC）的激活涉及从静止状态向增殖、迁移和纤维化表型（即肌成纤维细胞）的转变，这是肝纤维化的特征。已经确定了多种促成HSC激活的细胞和分子信号。本综述特别关注影响HSC激活和纤维化的代谢变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77f8/6240744/e216d83253ef/fcell-06-00150-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77f8/6240744/fc2976560474/fcell-06-00150-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77f8/6240744/e8145a395a63/fcell-06-00150-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77f8/6240744/09b1ef5e9112/fcell-06-00150-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77f8/6240744/e06eacb268ac/fcell-06-00150-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77f8/6240744/e216d83253ef/fcell-06-00150-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77f8/6240744/fc2976560474/fcell-06-00150-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77f8/6240744/e8145a395a63/fcell-06-00150-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77f8/6240744/09b1ef5e9112/fcell-06-00150-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77f8/6240744/e06eacb268ac/fcell-06-00150-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77f8/6240744/e216d83253ef/fcell-06-00150-g005.jpg

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