Makuuchi Masatoshi
President Emeritus, Towa Hospital, 4-7-10 Towa, Adachi-ku, Tokyo, 120-0003, Japan.
Surg Today. 2019 Apr;49(4):288-294. doi: 10.1007/s00595-018-1744-6. Epub 2018 Nov 27.
Since I moved from the National Cancer Center to Shinshu University, I have been performing living donor liver transplantation (LDLT), which is the only way to save the life of patients with end-stage liver disease. In June 1990, we performed the first LDLT that case was the first successful case in Japan. The patient remains healthy and is enjoying a normal life still 28 years after the transplant. In 1993, we successfully performed adult-to-adult LDLT, which was the first successful case in the world. The patient enjoyed a normal life for 17 years until she died at 70 years of age. For small children, the left liver of adult donors is too large to close the abdomen. However, in adolescents or adults, even when the whole right liver is used, the volume of the graft is too small. The concept of the standard liver volume (SLV) has proven very important for this procedure and is calculated as follows: 706.2 × body surface area + 2.4. We proposed a method for evaluating the congestion of the liver by Doppler ultrasound. In addition, we devised the right lateral sector graft. Over the years, we have contributed to LDLT in many ways and published many papers. We feel that our findings are quite useful not only for LDLT but also for other hepatectomy procedures.
自从我从国立癌症中心调到信州大学后，我一直在进行活体肝移植（LDLT），这是挽救终末期肝病患者生命的唯一方法。1990年6月，我们进行了首例LDLT，该病例是日本首例成功案例。该患者仍然健康，移植后28年仍过着正常生活。1993年，我们成功进行了成人对成人的LDLT，这是世界上首例成功案例。该患者正常生活了17年，直到70岁去世。对于幼儿来说，成人供体的左肝太大，无法关闭腹部。然而，对于青少年或成年人，即使使用整个右肝，移植肝的体积也太小。标准肝体积（SLV）的概念已被证明对该手术非常重要，其计算方法如下：706.2×体表面积 + 2.4。我们提出了一种通过多普勒超声评估肝脏充血情况的方法。此外，我们设计了右外侧叶移植。多年来，我们在很多方面为LDLT做出了贡献，并发表了许多论文。我们认为我们的研究结果不仅对LDLT，而且对其他肝切除手术都非常有用。
