Orthopedic Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Chin J Integr Med. 2019 May;25(5):370-377. doi: 10.1007/s11655-018-2565-6. Epub 2018 Nov 27.
To summarize and critically assess the inhibitory effects of Chinese herbal medicine (CHM) on tumor volume and tumor weight for the treatment of osteosarcoma (OS) in mouse models.
PubMed, Embase, Web of Science, China Knowledge Resource Integrated Database (CNKI), Wanfang Database, VIP Database, and Chinese BioMedical (CBM) were searched since their inception dates to March 10, 2016. Two reviewers independently selected the controlled studies estimating effects of CHM on mouse OS by administration in vivo. A pair-wise meta-analysis was performed. Twenty-five studies with adequate randomization were included in the systematic review.
CHM may significantly inhibit OS growth in mice, as assessed using the tumor weight [20 studies, n=443; 290 for CHM and 153 for the control: pooled mean difference (MD)=-2.90; 95% confidence interval (Cl): -3.50 to -2.31: P<0.01], tumor volume (16 studies, n=382; 257 for CHM and 125 for the control; pooled MD =-2.57; 95% Cl: -3.33 to -1.80; P<0.01) and tumor growth inhibition rate.
CHM could significantly inhibit the growth of OS in mouse models, which might be supportive for the design of preclinical and clinical trials in future.
总结和评估中药（CHM）对肿瘤体积和肿瘤重量的抑制作用，以治疗骨肉瘤（OS）的小鼠模型。
检索PubMed、Embase、Web of Science、中国知识资源总库（CNKI）、万方数据库、维普数据库和中国生物医学文献数据库（CBM），检索时间从建库至 2016 年 3 月 10 日。两名评价者独立筛选了通过体内给药评估 CHM 对 OS 作用的对照研究。进行了成对的荟萃分析。系统评价共纳入 25 项研究，涉及 443 只接受 CHM 治疗的小鼠和 153 只接受对照治疗的小鼠。
中药可能显著抑制 OS 的生长，用肿瘤重量评估[20 项研究，n=443；290 只为 CHM 治疗组，153 只为对照组：合并均数差（MD）=-2.90；95%置信区间（CI）：-3.50 至-2.31：P<0.01]，肿瘤体积（16 项研究，n=382；257 只为 CHM 治疗组，125 只为对照组：合并 MD =-2.57；95%CI：-3.33 至-1.80；P<0.01）和肿瘤生长抑制率。
中药可能显著抑制 OS 在小鼠模型中的生长，这可能为未来的临床前和临床试验设计提供支持。
