Brain and Neurodegenerative Disorders Research Laboratory, Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, 34098, Istanbul, Turkey.
Hormones (Athens). 2019 Mar;18(1):17-21. doi: 10.1007/s42000-018-0087-4. Epub 2018 Nov 27.
Vitamin D, a secosteroid hormone, has, over the years, mainly been known for its classic role in the maintenance of calcium homeostasis of the human body. However, there is increasing understanding that vitamin D contributes to the regulation of Ca homeostasis, especially via voltage-gated calcium channels, in another major organ that uses calcium, the brain. Almost 30 years ago, the role of dysregulation in the aging brain and in Alzheimer's disease (AD) gave rise to the Ca hypothesis of brain aging and dementia. We thus made calcium homeostasis the starting point of our studies, proposing the notion that the consequences of long-term deficiency and/or inefficient utilization of vitamin D may cause the disruption of calcium homeostasis in neurons, this creating a vulnerability of neurons to aging and neurodegeneration. In this mini-review, we aim to describe the potential of vitamin D (cholecalciferol) as a neurosteroid based on our findings and conclusions.
维生素 D 是一种类固醇激素，多年来，它主要因其在维持人体钙平衡方面的经典作用而闻名。然而，人们越来越认识到，维生素 D 有助于调节钙平衡，特别是通过电压门控钙通道，在另一个大量使用钙的主要器官——大脑中。大约 30 年前，大脑衰老和阿尔茨海默病（AD）中的失调作用提出了大脑衰老和痴呆症的钙假说。因此，我们将钙稳态作为我们研究的起点，提出长期缺乏和/或维生素 D 利用效率低下可能导致神经元钙稳态紊乱的观点，这使得神经元容易受到衰老和神经退行性变的影响。在这篇简短的综述中，我们旨在根据我们的发现和结论，描述维生素 D（胆钙化醇）作为神经甾体的潜力。
