PAQosome 在调节蛋白质四级结构的排列中的作用：健康与疾病。
Role of the PAQosome in Regulating Arrangement of Protein Quaternary Structure in Health and Disease.
机构信息
Institut de Recherches Cliniques de Montréal, QC, Canada.
Department of Biochemistry and Molecular Medicine, Université de Montréal, QC, Canada.
出版信息
Adv Exp Med Biol. 2018;1106:25-36. doi: 10.1007/978-3-030-00737-9_3.
The PAQosome, formerly known as the R2TP/PFDL complex, is an eleven-subunit cochaperone complex that assists HSP90 in the assembly of numerous large multisubunit protein complexes involved in essential cellular functions such as protein synthesis, ribosome biogenesis, transcription, splicing, and others. In this review, we discuss possible mechanisms of action and role of phosphorylation in the assembly of client complexes by the PAQosome as well as its potential role in cancer, ciliogenesis and ciliopathies.
PAQosome，前称为 R2TP/PFDL 复合物，是一个由 11 个亚基组成的共伴侣复合物，可协助 HSP90 组装许多参与基本细胞功能的大型多亚基蛋白复合物，如蛋白质合成、核糖体生物发生、转录、剪接等。在这篇综述中，我们讨论了 PAQosome 在组装客户复合物过程中磷酸化的作用机制及其在癌症、纤毛发生和纤毛病中的潜在作用。
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