PAQosome，一种基于 R2TP 的四级结构形成伴侣。

The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation.

机构信息

Department of Biochemistry, University of Toronto, Toronto, Ontario M5G 1M1, Canada; Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.

IGMM, CNRS, Université de Montpellier, Montpellier, France; Equipe labélisée Ligue Nationale Contre le Cancer, IGMM - CNRS UMR5535, 1919 route de Mende, 34293 Montpellier 5, France.

出版信息

Trends Biochem Sci. 2018 Jan;43(1):4-9. doi: 10.1016/j.tibs.2017.11.001. Epub 2017 Dec 5.

DOI:10.1016/j.tibs.2017.11.001

PMID:29203338

Abstract

The Rvb1-Rvb2-Tah1-Pih1/prefoldin-like (R2TP/PFDL) complex is a unique chaperone that provides a platform for the assembly and maturation of many key multiprotein complexes in mammalian cells. Here, we propose to rename R2TP/PFDL as PAQosome (particle for arrangement of quaternary structure) to more accurately represent its unique function.

摘要

Rvb1-Rvb2-Tah1-Pih1/ Prefoldin-like（R2TP/PFDL）复合物是一种独特的伴侣蛋白，它为哺乳动物细胞中许多关键多蛋白复合物的组装和成熟提供了一个平台。在这里，我们建议将 R2TP/PFDL 重新命名为 PAQosome（四级结构组装颗粒），以更准确地表示其独特的功能。