钯(0)/羧酸联合催化的双向炔烃串联异构化反应：制备 1,3-二烯的便捷途径。
Bi-directional alkyne tandem isomerization via Pd(0)/carboxylic acid joint catalysis: expedient access to 1,3-dienes.
机构信息
Università di Parma, Dipartimento di Scienze Chimiche, della Vita e della Sostenibilità Ambientale, 17/A Parco Area delle Scienze, 43124 Parma, Italy.
出版信息
Chem Commun (Camb). 2018 Dec 11;54(99):14021-14024. doi: 10.1039/c8cc08561g.
An in situ formed palladium hydride catalyst enables the sequential dual isomerization of propargylamide derivatives to 1-amido-1,3-dienes with high chemo- and regioselectivity. The reaction shows ample functional group tolerance, delivering a valuable class of products, including highly deuterated ones, from readily available reagents. The reaction occurs through a complex mechanism studied by DFT modelling.
原位形成的钯氢化物催化剂能够实现炔丙酰胺衍生物的顺序双重异构化，生成具有高化学和区域选择性的 1-酰胺-1,3-二烯。该反应具有广泛的官能团容忍性，能够从易得的试剂中提供有价值的一类产物，包括高度氘化的产物。通过 DFT 建模研究了反应的复杂机制。
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