Traoré K, Coulibaly S P, Tembely M B, Togora A, Coulibaly S, Koumaré B
Service de psychiatrie CHU du Point G.
Faculté de Médecine et d'Odontostomatologie.
Mali Med. 2018;33(2):1-4.
Autism is a global and early developmental disorder that appears before the age 3 years old. It is characterized by a triad of symptoms affecting the following domains: social interaction, verbal and non-verbal communication, imagination and behaviors. This work aimed to determine the frequency of autism and to identify its risk factors in Malians aged 0-17 years old.
In a cross sectional and prospective study, we reviewed clinical data in 2068 medical charts dating from 1992 to 2012 from all the mental health care centers in Bamako.
We found a frequency of 7.8% (162/2068). The age range 0-5 years old was the most represented. The sex ratio was 1.7. The autistic child was issued from a consanguineous marriage in 25.4% (41/162) of the cases. To have parents in divorce, being the first child, and male gender were associated with autism with statistical significance. Our data suggest an elevated number of autism cases in Mali. We plan to carry out a larger prospective study to determine other autism risk factors and importantly to identify autistic families for a molecular genetic study.
自闭症是一种全球性的早期发育障碍，出现在3岁之前。它的特征是影响以下领域的一组三联征症状：社交互动、言语和非言语交流、想象力和行为。这项研究旨在确定马里0至17岁人群中自闭症的发病率，并确定其风险因素。
在一项横断面前瞻性研究中，我们回顾了1992年至2012年来自巴马科所有精神卫生保健中心的2068份病历中的临床数据。
我们发现发病率为7.8%（162/2068）。0至5岁年龄组占比最大。男女比例为1.7。25.4%（41/162）的自闭症儿童出生于近亲婚姻家庭。父母离异、身为长子以及男性性别与自闭症存在统计学意义上的关联。我们的数据表明马里的自闭症病例数有所增加。我们计划开展一项更大规模的前瞻性研究，以确定其他自闭症风险因素，重要的是识别出自闭症家庭以便进行分子遗传学研究。
