State Key Laboratory of Reproductive Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University/Jiangsu Province Hospital, Nanjing Medical University, Nanjing, China.
J Womens Health (Larchmt). 2018 Dec;27(12):1508-1512. doi: 10.1089/jwh.2018.6935. Epub 2018 Nov 28.
To determine the prevalence of stress urinary incontinence (SUI) and associated factors in women with premature ovarian insufficiency (POI). The study included 149 patients with POI and 303 control women without POI. Age, body mass index (BMI), gestational history, time since onset of POI, and status of hormone therapy (HT) for POI were recorded. There was no statistical difference in the mean age, BMI, and parity between the two groups. The prevalence of SUI in the POI group tended to be higher than that in the control group (20.9%, 30/149 vs. 16.2%, 49/303), although not significantly ( = 0.297). About 41.6% (62/149) of patients with POI received HT. Patients with POI and SUI were older ( = 0.018) and had higher BMI ( = 0.007) than women with POI without SUI ( = 0.007). Compared to nulliparas, primiparas were more likely to have SUI ( = 0.046). However, SUI developed irrespective of time since onset of oligomenorrhea/amenorrhea or HT use. Furthermore, regression analysis showed that the prevalence of SUI was higher in women 30-39 years of age (odds ratio [OR] = 3.27, = 0.002) and older than 40 years (OR = 7.78, = 0.001). Primiparas (OR = 2.89, = 0.001) and vaginal delivery (OR = 2.58, = 0.023) were associated with SUI. The prevalence of SUI was fairly high among patients with POI, and age, parity, and vaginal delivery were the main risk factors. However, duration of POI and HT use had no effect on SUI. Increasing awareness of the importance of urinary system health in this population will improve the quality of life for these women.
确定早发性卵巢功能不全（POI）女性压力性尿失禁（SUI）的患病率及相关因素。
本研究纳入了 149 例 POI 患者和 303 例非 POI 对照女性。记录年龄、体重指数（BMI）、妊娠史、POI 发病时间和 POI 激素治疗（HT）状态。两组间的平均年龄、BMI 和产次无统计学差异。POI 组的 SUI 患病率似乎高于对照组（20.9%，30/149 比 16.2%，49/303），但无统计学意义（ = 0.297）。约 41.6%（62/149）的 POI 患者接受了 HT。POI 和 SUI 患者的年龄较大（ = 0.018），BMI 较高（ = 0.007），与无 SUI 的 POI 患者相比（ = 0.007）。与经产妇相比，初产妇更易发生 SUI（ = 0.046）。然而，SUI 的发生与月经稀发/闭经时间或 HT 使用无关。此外，回归分析显示，30-39 岁女性（比值比 [OR] = 3.27， = 0.002）和年龄大于 40 岁的女性（OR = 7.78， = 0.001）SUI 患病率较高。初产妇（OR = 2.89， = 0.001）和阴道分娩（OR = 2.58， = 0.023）与 SUI 相关。POI 患者的 SUI 患病率相当高，年龄、产次和阴道分娩是主要危险因素。然而，POI 发病时间和 HT 使用对 SUI 无影响。提高对该人群泌尿系统健康重要性的认识将提高这些女性的生活质量。
