一例环孢素意外过量服用及其药代动力学分析
A case of accidental cyclosporin overdose with pharmacokinetic analysis.
作者信息
Krüger H U, Bross-Bach U, Proksch B, Schmidt H, Dopfer R, Ehninger G
机构信息
Medizinische Universitätsklinik, Tübingen, FRG.
出版信息
Bone Marrow Transplant. 1988 Mar;3(2):167-9.
PMID:3048482
Abstract
In a case of oral overdose of cyclosporin we measured plasma concentrations by radioimmunoassay and high pressure liquid chromatography. We observed unchanged pharmacokinetic parameters after the overdose indicating normal renal and hepatic function. Laboratory findings showed no renal or hepatic damage. As toxic symptoms, only emesis and a short, mild drowsiness were noted.
摘要
在一例口服环孢素过量的病例中，我们通过放射免疫测定法和高压液相色谱法测量了血浆浓度。我们观察到过量服药后药代动力学参数未变，表明肾和肝功能正常。实验室检查结果显示没有肾或肝损伤。作为中毒症状，仅注意到呕吐和短暂、轻度嗜睡。
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