Weiss L, Bullorsky E, Ashkenazi Y J, Slavin S
Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel.
Bone Marrow Transplant. 1988 May;3(3):207-10.
The optimal time interval between termination of radiation therapy and marrow grafting has been studied in an animal model of syngeneic bone marrow transplantation, using a limiting number of bone marrow cells. Optimal survival was achieved when reconstitution took place 24 h following termination of radiation therapy at all cell doses studied, including 5 x 10(4), 2 x 10(5) and 1 x 10(6) cells/recipient. The worst results were observed when bone marrow cells were infused immediately after irradiation. These results suggest that reconstitution of lethally irradiated recipients requires migration of irradiated host marrow cells and establishment of adequate 'bone marrow space', which is optimal at 24 h following termination of whole body irradiation.
在同基因骨髓移植的动物模型中，使用有限数量的骨髓细胞，研究了放射治疗结束与骨髓移植之间的最佳时间间隔。在所研究的所有细胞剂量下，包括5×10⁴、2×10⁵和1×10⁶个细胞/受体，当在放射治疗结束后24小时进行重建时，可实现最佳存活。当骨髓细胞在照射后立即注入时，观察到最差的结果。这些结果表明，对接受致死性照射的受体进行重建需要照射后的宿主骨髓细胞迁移并建立足够的“骨髓空间”，而这在全身照射结束后24小时最为理想。
