Akiyama M, Nonomura M, Tero A, Kobayashi R
Research Institute for Electronic Science, Hokkaido University, Kita 12, Nishi 7, Kita-ku, Sapporo-shi, Hokkaido 060-0812, Japan. These authors contributed equally to this work.
Phys Biol. 2018 Nov 28;16(1):016005. doi: 10.1088/1478-3975/aaee45.
A method of numerical simulation of cell division using phase fields is presented. The cell division plane is obtained as a result of the spindle position and orientation considered with the spatial distribution of the activated cortical force generators and the dividing cell shape. To exemplify the application of the proposed method, numerical simulations of the development of cysts and early embryos are performed. The numerical results demonstrate that the activated cortical force generators that are localized at the lateral cortices of the epithelial cells lead to the formation of a single central lumen. It is additionally shown that the linear distribution of the activated cortical force generators along the animal-vegetal axis of a spherical cell engenders a similar cell proliferation of the divided embryo generated by the 32 cell period in a sea cucumber.
提出了一种使用相场对细胞分裂进行数值模拟的方法。细胞分裂平面是通过考虑纺锤体的位置和方向以及活化的皮质力发生器的空间分布和分裂细胞形状而得到的。为了举例说明所提出方法的应用，对囊肿和早期胚胎的发育进行了数值模拟。数值结果表明，位于上皮细胞外侧皮质的活化皮质力发生器导致单个中央管腔的形成。此外还表明，活化皮质力发生器沿球形细胞的动物 - 植物轴的线性分布会导致海参中由32细胞期产生的分裂胚胎出现类似的细胞增殖。
