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探索印度不同疫苗接种覆盖率剂量的空间异质性。

Exploring the spatial heterogeneity in different doses of vaccination coverage in India.

机构信息

International Institute for Population Sciences (IIPS), Mumbai, India.

Karnataka Health Promotion Trust (KHPT), Bangalore, India.

出版信息

PLoS One. 2018 Nov 28;13(11):e0207209. doi: 10.1371/journal.pone.0207209. eCollection 2018.

Abstract

BACKGROUND

Despite the universalization of immunization against the six vaccine-preventable diseases (VPDs), the coverage of full immunization among the children under age five has remained a challenge globally. The 2015-16 National Family Health Survey (NFHS) indicated large disparity in the coverage of different vaccination doses (BCG, Polio, DPT and Measles) including full immunization across the districts of India. The spatial distribution of poor performing districts in terms of vaccination and the district level spatial, contextual determinants contributing to the low coverage have been poorly studied. Using the recent household survey (NFHS, 2015-16), this study examined the spatial heterogeneity and the factors associated with low vaccination coverage among the children aged 12-23 months across India.

DATA AND METHODS

This study used the data from fourth round of National Family Health Survey conducted in 2015-16. District-level prevalence of each of the vaccination doses including full immunization, were analysed. Moran's I, Univariate and Bivariate LISA, Ordinary least square (OLS) and spatial models were employed to achieve the overall aim of the study.

RESULTS

At the national level, the prevalence of full immunization was 62 percent. Specific vaccination coverage for BCG, three doses of polio, three doses of DPT and measles were 92, 73, 78 and 81 percent, respectively. The value of the bivariate Moran's I statistics confirmed the spatial dependence between specific vaccination and the set of independent variables. District-level prevalence of the specific vaccine and full immunization showed significant spatial clustering across India. The adjusted coefficients from the spatial error model confirmed that district-level proportion of utilization of post-natal care, institutional births, neonatal tetanus protection of the last birth, women's education and coverage of health insurance showed statistically significant association with every doses of vaccination coverage.

CONCLUSION

The full and specific immunization coverage was considerably low in the geographical hotspots as compared to the national coverage. Maternal and child health care services utilization, financial assistance to the mothers through JSY scheme and mother's education were found to determine full immunization as well as the specific vaccination coverage. Appropriate intervention should be designed to reduce the geographical disparity in the coverage of specific and full immunization across India and thus safeguard child health protecting the children from the vaccine preventable diseases across the geography.

摘要

背景

尽管全球范围内已经普及了针对六种疫苗可预防疾病(VPDs)的免疫接种,但五岁以下儿童完全免疫接种的覆盖率仍然是一个全球性挑战。2015-16 年全国家庭健康调查(NFHS)表明,印度各地区之间不同疫苗剂量(卡介苗、脊髓灰质炎、DPT 和麻疹)的接种覆盖率,包括完全免疫接种,存在很大差异。在接种方面表现不佳的地区的空间分布以及导致低覆盖率的地区层面空间和背景决定因素,研究得还很不完善。本研究利用最近的家庭调查(NFHS,2015-16 年),研究了印度 12-23 个月儿童疫苗接种覆盖率低的空间异质性和相关因素。

数据和方法

本研究使用了 2015-16 年进行的第四次全国家庭健康调查的数据。分析了每个疫苗剂量(包括完全免疫接种)的区级流行率。采用 Moran's I、单变量和双变量局部空间自相关(LISA)、普通最小二乘法(OLS)和空间模型来实现研究的总体目标。

结果

在全国范围内,完全免疫接种的流行率为 62%。卡介苗、三剂脊髓灰质炎、三剂 DPT 和麻疹的特定疫苗接种覆盖率分别为 92%、73%、78%和 81%。双变量 Moran's I 统计量的值证实了特定疫苗接种和一组独立变量之间的空间依赖性。印度各地的特定疫苗和完全免疫接种的区级流行率显示出显著的空间聚类。空间误差模型的调整系数证实,区级利用产后护理、机构分娩、新生儿破伤风保护最后一次分娩、妇女教育和医疗保险覆盖率与每种疫苗接种覆盖率均呈统计学显著关联。

结论

与全国覆盖率相比,地理热点地区的完全和特定免疫接种覆盖率相当低。通过 JSY 计划为母亲提供母婴保健服务利用、经济援助和母亲教育被发现可以决定完全免疫接种以及特定疫苗接种覆盖率。应该设计适当的干预措施,以减少印度各地特定和完全免疫接种覆盖率的地理差异,从而保障儿童健康,保护儿童免受各地疫苗可预防疾病的侵害。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fd/6261550/e22e6cd0ed54/pone.0207209.g001.jpg

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