Zhao Li-Juan, Zhang Ting, Feng Xue-Jian, Chang Jiao, Suo Feng-Zhi, Ma Jin-Lian, Liu Ying-Jun, Liu Ying, Zheng Yi-Chao, Liu Hong-Min
Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Institute of Drug Discovery and Development, Zhengzhou University, Zhengzhou, Henan, China.
Henan Cancer Hospital, Zhengzhou University, Zhengzhou, Henan, China.
J Cell Biochem. 2019 May;120(5):7657-7666. doi: 10.1002/jcb.28040. Epub 2018 Nov 28.
USP28, a member of the deubiquitinating enzymes family, plays a vital role in the physiological process of cell proliferation, differentiation and apoptosis, DNA repair, immune response, and stress response. USP28 has been reported to be overexpressed in bladder cancer, colon cancer, breast carcinomas, and so on. Nevertheless, the role of USP28 in gastric cancer has not yet been investigated. In our study, we examined the USP28 expression in 87 paired samples of gastric cancer and normal gastric tissues. We found that USP28 was overexpressed in gastric cancer compared with normal gastric tissues (P < 0.01), and its overexpression was related to the degree of differentiation and metastases. Inhibiting USP28 expression in vitro suppressed the proliferation and invasion of gastric cancer cells by downregulating lysine specific demethylase 1. On the basis of our data, it can be concluded that USP28 may be a novel therapeutic target for gastric cancer.
泛素特异性蛋白酶28（USP28）是去泛素化酶家族的成员之一，在细胞增殖、分化和凋亡、DNA修复、免疫反应及应激反应等生理过程中发挥着至关重要的作用。据报道，USP28在膀胱癌、结肠癌、乳腺癌等肿瘤中呈过表达。然而，USP28在胃癌中的作用尚未见研究报道。在本研究中，我们检测了87对胃癌组织和正常胃组织样本中USP28的表达情况。我们发现，与正常胃组织相比，USP28在胃癌组织中呈过表达（P < 0.01），且其过表达与肿瘤的分化程度及转移有关。体外抑制USP28的表达可通过下调赖氨酸特异性去甲基化酶1来抑制胃癌细胞的增殖和侵袭。基于我们的数据，可以得出结论，USP28可能是胃癌的一个新的治疗靶点。
