miR-4295在人类癌症中的矛盾作用：对发病机制和个性化医学的启示。
The paradoxical roles of miR-4295 in human cancer: Implications in pathogenesis and personalized medicine.
作者信息
Li Yin, Zhang Yihan, Zou Yuhao, Duan Shiwei
机构信息
Medical Genetics Center, Ningbo University School of Medicine, Ningbo, Zhejiang 315211, PR China.
出版信息
Genes Dis. 2020 Oct 6;9(3):638-647. doi: 10.1016/j.gendis.2020.09.007. eCollection 2022 May.
MiR-4295, located on chromosome 10q25.2, is a unique miRNA with a wide range of biological functions. miR-4295 is widely expressed , participating in the biological processes of multiple cancers. Although miR-4295 is dysregulated in various cancers, it has also been found to have the function of inhibiting cancer. At the same time, the expression of miR-4295 is related to prognosis and can be affected by numerous factors connecting to the therapeutic effects of various drugs. This article is to better summarize the role of miR-4295 in cancer and review the potential diagnostic, prognostic, and therapeutic value of miR-4295, which may provide insight into subsequent research.
MiR-4295位于10号染色体q25.2区域，是一种具有广泛生物学功能的独特微小RNA。MiR-4295广泛表达，参与多种癌症的生物学过程。尽管MiR-4295在各种癌症中表达失调，但也发现它具有抑制癌症的功能。同时，MiR-4295的表达与预后相关，并且会受到与各种药物治疗效果相关的众多因素的影响。本文旨在更好地总结MiR-4295在癌症中的作用，并综述MiR-4295潜在的诊断、预后和治疗价值，这可能为后续研究提供思路。
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