Li Yin, Zhang Yihan, Zou Yuhao, Duan Shiwei
Medical Genetics Center, Ningbo University School of Medicine, Ningbo, Zhejiang 315211, PR China.
Genes Dis. 2020 Oct 6;9(3):638-647. doi: 10.1016/j.gendis.2020.09.007. eCollection 2022 May.
MiR-4295, located on chromosome 10q25.2, is a unique miRNA with a wide range of biological functions. miR-4295 is widely expressed , participating in the biological processes of multiple cancers. Although miR-4295 is dysregulated in various cancers, it has also been found to have the function of inhibiting cancer. At the same time, the expression of miR-4295 is related to prognosis and can be affected by numerous factors connecting to the therapeutic effects of various drugs. This article is to better summarize the role of miR-4295 in cancer and review the potential diagnostic, prognostic, and therapeutic value of miR-4295, which may provide insight into subsequent research.
MiR-4295位于10号染色体q25.2区域，是一种具有广泛生物学功能的独特微小RNA。MiR-4295广泛表达，参与多种癌症的生物学过程。尽管MiR-4295在各种癌症中表达失调，但也发现它具有抑制癌症的功能。同时，MiR-4295的表达与预后相关，并且会受到与各种药物治疗效果相关的众多因素的影响。本文旨在更好地总结MiR-4295在癌症中的作用，并综述MiR-4295潜在的诊断、预后和治疗价值，这可能为后续研究提供思路。
