Sodergren Samantha C, Husson Olga, Rohde Gudrun E, Tomaszewska Iwona M, Griffiths Helen, Pessing Aya, Yarom Noam, Hooker Louise, Din Amy, Darlington Anne Sophie
School of Health Sciences, University of Southampton, Southampton, UK.
Institute of Cancer Research, London, UK.
Eur J Cancer Care (Engl). 2018 Nov;27(6):e12980. doi: 10.1111/ecc.12980.
Health-related quality of life (HRQoL) concerns of adolescents and young adults (AYAs) aged 14-25 years were compared with those of older adults (26-60 years) with cancer.
AYAs and older adults receiving curative intent treatment or supportive palliative care for cancer were recruited from eight research centres across Europe. Participants used a rating scale to score the relevance and importance of a list of 77 issues covering 10 areas of HRQoL concern: symptoms; activity restrictions; social; emotional; body image; self-appraisals; outlook on life; lifestyle; treatment-related and life beyond treatment.
HRQoL issues were reviewed by 33 AYAs and 25 older adults. Several issues were recognised as relevant and important across all age groups: symptoms, emotional impact, outlook on life, lifestyle and treatment-related. A number of issues were more relevant or important to AYAs including interrupted education, greater motivation to achieve academic goals, increased maturity, boredom, fertility and change in living situation.
While there is overlap in several of the HRQoL concerns across the age span, it is important that HRQoL measures used with AYAs capture the diverse and unique psychosocial aspects of this developmental stage.
比较14至25岁青少年及青年成人（AYAs）与26至60岁癌症成年患者在健康相关生活质量（HRQoL）方面的关注点。
从欧洲八个研究中心招募接受癌症根治性治疗或支持性姑息治疗的AYAs和成年患者。参与者使用评分量表对涵盖HRQoL关注的10个领域的77个问题列表的相关性和重要性进行评分：症状；活动受限；社交；情绪；身体形象；自我评估；生活展望；生活方式；治疗相关及治疗后的生活。
33名AYAs和25名成年患者对HRQoL问题进行了评估。几个问题在所有年龄组中都被认为是相关且重要的：症状、情绪影响、生活展望、生活方式和治疗相关问题。一些问题对AYAs更相关或更重要，包括教育中断、实现学术目标的更大动力、成熟度增加、无聊、生育能力和生活状况变化。
虽然不同年龄段在HRQoL关注方面存在一些重叠，但重要的是，用于AYAs的HRQoL测量方法要能捕捉到这个发育阶段多样且独特的心理社会方面。
