Department of Molecular, Cellular and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO 80309-0347, USA
University of Colorado Comprehensive Cancer Center, Anschutz Medical Campus, 13001 E. 17th Pl., Aurora, CO 80045, USA.
Open Biol. 2018 Nov 28;8(11):180157. doi: 10.1098/rsob.180157.
The ability to regenerate is a fundamental requirement for tissue homeostasis. Regeneration draws on three sources of cells. First and best-studied are dedicated stem/progenitor cells. Second, existing cells may proliferate to compensate for the lost cells of the same type. Third, a different cell type may change fate to compensate for the lost cells. This review focuses on regeneration of the third type and will discuss the contributions by post-transcriptional mechanisms including the emerging evidence for cell-autonomous and non-lethal roles of cell death pathways.
再生能力是组织稳态的基本要求。再生利用三种细胞来源。首先也是研究得最好的是专门的干细胞/祖细胞。其次，现有细胞可能增殖以补偿相同类型的丢失细胞。第三，不同的细胞类型可能改变命运以补偿丢失的细胞。本综述重点讨论第三种类型的再生，并将讨论包括细胞自主和非致命性细胞死亡途径的新兴证据在内的转录后机制的贡献。
