Noeypatimanond S, Malikul S, Benjapong W, Duriyananda D, Ungkasrithongkul M
Trans R Soc Trop Med Hyg. 1983;77(3):338-40. doi: 10.1016/0035-9203(83)90158-x.
A combination of the drugs amodiaquine and tetracycline was used in a clinical trial at Phrabuddhabat Hospital in Central Thailand for treating Plasmodium falciparum malaria. Of the 51 patients who completed the 28-day follow-up, 49 (96%) were cured; in two cases the parasitaemia was cleared within seven days of initial therapy but returned within 28 days (RI response). Only one patient experienced a mild and transient side effect of nausea. The treatment regimen was cheap and the drugs are readily available commercially. Results of this study suggest that amodiaquine-tetracycline combination offers a practical, safe and highly effective method for treating uncomplicated falciparum malaria.
泰国中部佛丕巴达医院在一项临床试验中使用阿莫地喹和四环素联合用药治疗恶性疟原虫疟疾。在完成28天随访的51例患者中，49例（96%）治愈；2例患者在初始治疗7天内疟原虫血症清除，但在28天内复发（RI反应）。仅1例患者出现轻微短暂的恶心副作用。该治疗方案成本低廉，药物在市场上易于获取。本研究结果表明，阿莫地喹-四环素联合用药为治疗非复杂性恶性疟提供了一种实用、安全且高效的方法。
