Pang L W, Limsomwong N, Karwacki J, Webster H K
Bull World Health Organ. 1988;66(3):359-63.
In a case-control study we examined the association of Plasmodium falciparum circumsporozoite antibodies (anti-R32tet32) with subsequent P. falciparum infections. A study population of 140 children living in an endemic area was followed longitudinally for 25 weeks with weekly blood smears for malaria parasites and, once every two weeks, serum samples for circumsporozoite antibody determinations. From the malaria cases, antibody measurements occurring between two and six weeks prior to the onset of parasitaemia were utilized. For each case, two controls were selected. The results from 17 cases and 34 controls failed to show a statistically significant difference in antibody levels prior to the infection (P=0.07, one-tailed Student's t-test). However, 8 of the 17 cases had antibody present, indicating a level that was not protective against patent infection.
在一项病例对照研究中，我们检测了恶性疟原虫环子孢子抗体（抗-R32tet32）与随后的恶性疟原虫感染之间的关联。对生活在疟疾流行地区的140名儿童组成的研究人群进行了为期25周的纵向跟踪，每周进行疟原虫血涂片检查，并每两周采集一次血清样本用于环子孢子抗体测定。从疟疾病例中，采用寄生虫血症发作前两至六周之间的抗体测量值。对于每个病例，选择两名对照。17例病例和34名对照的结果未能显示感染前抗体水平有统计学上的显著差异（P = 0.07，单尾学生t检验）。然而，17例病例中有8例存在抗体，这表明该抗体水平对显性感染没有保护作用。
