Lara Evelyn, Acurio Jesenia, Leon José, Penny Jeffrey, Torres-Vergara Pablo, Escudero Carlos
Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (LFV-GIANT), Department of Basic Sciences, Faculty of Basic Sciences, Universidad del Bío-Bío, Chillán, Chile.
Group of Research and Innovation in Vascular Health (GRIVAS Health), Chillán, Chile.
Front Physiol. 2018 Nov 14;9:1591. doi: 10.3389/fphys.2018.01591. eCollection 2018.
Evidence from clinical studies has proposed that children born from preeclamptic women have a higher risk of suffering neurological, psychological, or behavioral alterations. However, to date, the mechanisms behind these outcomes are poorly understood. Here, we speculate that the neurodevelopmental alterations in the children of preeclamptic pregnancies result from impaired angiogenesis. The pro-angiogenic factors vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) are key regulators of both vascular and neurological development, and it has been widely demonstrated that umbilical blood of preeclamptic pregnancies contains high levels of soluble VEGF receptor type 1 (sFlt-1), a decoy receptor of VEGF. As a consequence, this anti-angiogenic state could lead to long-lasting neurological outcomes. In this non-systematic review, we propose that alterations in the circulating concentrations of VEGF, PlGF, and sFlt-1 in preeclamptic pregnancies will affect both fetal cerebrovascular function and neurodevelopment, which in turn may cause cognitive alterations in post-natal life.
临床研究证据表明，子痫前期孕妇所生的孩子出现神经、心理或行为改变的风险更高。然而，迄今为止，这些结果背后的机制仍知之甚少。在此，我们推测子痫前期妊娠所生孩子的神经发育改变是由血管生成受损所致。促血管生成因子血管内皮生长因子（VEGF）和胎盘生长因子（PlGF）是血管和神经发育的关键调节因子，并且已有广泛证据表明子痫前期妊娠的脐血中含有高水平的可溶性血管内皮生长因子受体1型（sFlt-1），即VEGF的诱饵受体。因此，这种抗血管生成状态可能导致长期的神经学后果。在这篇非系统性综述中，我们提出子痫前期妊娠中VEGF、PlGF和sFlt-1循环浓度的改变会影响胎儿脑血管功能和神经发育，进而可能导致出生后生活中的认知改变。
