Predictive validity of the Sidorkiewicz instrument in Spanish: Assessing individual drug adherence in psychiatric patients.

Concomitant prescription of two or more psychiatric medications has become the rule and patients could adhere differently to their various drugs prescribed. Sidorkiewicz et al. published a questionnaire for assessing adherence to each specific drug. This study explored the predictive validity of the Spanish version of the Sidorkiewicz questionnaire in a sample of 470 consecutive psychiatric outpatients using 897 psychiatric drugs. The questionnaire showed adequate predictive validity in both univariate and multivariate analyses (logistic regression and CHAID segmentation) since they demonstrated a significant association with the 10-item Drug Attitude Inventory and with the Necessity and Concern Scales of the Beliefs about Medications Questionnaire. Some demographic and clinical variables were significant in the univariate analyses but lost significance in the multivariate analyses. The adherence of the psychiatric patient to his/her prescribed treatment may not be significantly influenced by socio-demographic or clinical characteristics, but rather by attitudes toward medication, perceptions of personal necessity for medication, and concerns about its potential adverse effects. This study's findings suggest that the Spanish version of the Sidorkiewicz questionnaire may be a useful and valid instrument for assessing adherence to each individual drug taken by psychiatric outpatients undergoing polypsychopharmacy.