Department of Internal Medicine, Dermatology and Psychiatry, Universidad de La Laguna, San Cristóbal de La Laguna, Spain.
Instituto Universitario de Neurociencia (IUNE), Universidad de La Laguna, San Cristóbal de La Laguna, Spain.
Hum Psychopharmacol. 2021 Jul;36(4):e2776. doi: 10.1002/hup.2776. Epub 2021 Jan 28.
We aimed to replicate a prior Spanish study of medication adherence where logistic regression models provided highly significant odds ratios (ORs) for three continuous scores: necessity, concern and the necessity-concern differential, and a dichotomous variable: skeptical attitude. Adherence ORs in the necessity-concern framework were very strong in patients taking five or six medications.
The sample comprised consecutive adult psychiatric outpatients in Mendoza, Argentina. The necessity-concerns framework was assessed using a subscale of the Beliefs about Medicines Questionnaire. Adherence (yes/no) to prescribed psychiatric medications was assessed by the Sidorkiewicz adherence tool.
When compared with the Spanish sample, the Argentinian group (508 patients with 875 medications) was characterized by: (1) significantly stronger adherence ORs with the necessity-concern framework, (2) significantly lower number of medications per patient and percentage of patients with marked psychiatric polypharmacy (≥4 medications), (3) though a higher number of medications still was significantly associated with poor adherence.
The Argentinian sample replicated the previous finding that patient beliefs regarding necessity and concern were associated with poor adherence to prescribed medications. Polypharmacy had an additive role decreasing adherence in both samples. In both samples, when prescribed ≥4 psychiatric medications, patients reported adherence to only two-third of the medications.
我们旨在复制先前一项西班牙研究，该研究采用逻辑回归模型对三个连续评分（必要性、关注和必要性-关注差异）和一个二分变量（怀疑态度）进行了高度显著的优势比（OR）分析。在需要关注框架中，服用五或六种药物的患者的依从性 OR 非常强。
该样本包括阿根廷门多萨的连续成年精神科门诊患者。使用药物信念量表的一个子量表评估必要性-关注框架。通过 Sidorkiewicz 依从性工具评估患者对规定精神科药物的依从性（是/否）。
与西班牙样本相比，阿根廷组（508 名患者，875 种药物）的特点是：（1）与必要性-关注框架相关的依从性 OR 显著更强，（2）每位患者的药物数量和有明显精神药物多药治疗（≥4 种药物）的患者比例显著较低，（3）尽管药物数量较多，但仍与较差的依从性显著相关。
阿根廷样本复制了先前的发现，即患者对必要性和关注的信念与规定药物的依从性差有关。在两个样本中，多药治疗都起到了降低依从性的附加作用。在两个样本中，当开处≥4 种精神科药物时，患者报告只服用了三分之二的药物。
