Kakurina G V, Kondakova I V, Spirina L V, Kolegova E S, Shashova E E, Cheremisina O V, Novikov V A, Choinzonov E L
Research Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of Sciences, Moscow, Russia.
Siberian State Medical University, Tomsk, Russia.
Bull Exp Biol Med. 2018 Dec;166(2):250-252. doi: 10.1007/s10517-018-4325-1. Epub 2018 Nov 28.
The model of head and neck squamous cell carcinoma (HNSCC) was used to study the expression of genes encoding actin-binding proteins depending on the type of cell motility. The expression of SNAIL1 and CAPN2 mRNA in HNSCC tissue was higher than in specimens of dysplastic epithelium of the larynx and hypopharynx, which can be explained by activation of mesenchymal and amoeboid types of cell motility. In biopsy material of HNSCC patients with T1-2N0M0, expression of genes responsible for actin-binding proteins differed from that of patients with pretumor pathology of the larynx and hypopharynx: expression of FSCN was lower, while expressions of EZR and CAP1 were higher. The data attest that progression of HNSCC is associated with activation of both types of cell motility and with the changes in the expression of mRNA encoding cell motility proteins.
利用头颈部鳞状细胞癌（HNSCC）模型，根据细胞运动类型研究编码肌动蛋白结合蛋白的基因表达。HNSCC组织中SNAIL1和CAPN2 mRNA的表达高于喉和下咽发育异常上皮标本，这可以通过间充质和阿米巴样细胞运动类型的激活来解释。在T1-2N0M0的HNSCC患者活检材料中，负责肌动蛋白结合蛋白的基因表达与喉和下咽肿瘤前病理患者不同：FSCN的表达较低，而EZR和CAP1的表达较高。数据证明，HNSCC的进展与两种细胞运动类型的激活以及编码细胞运动蛋白的mRNA表达变化有关。
