Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Bull Exp Biol Med. 2020 Aug;169(4):504-507. doi: 10.1007/s10517-020-04918-2. Epub 2020 Sep 11.
We analyzed the expression of genes encoding proteins involved in cytoskeleton remodeling (RND3, SNAI1, vimentin, cofilin, adenylate cyclase-associated protein 1, ezrin, and profilin) depending on the level of expression of protein phosphatase 1B (PPM1B) mRNA on the example of squamous cell carcinoma of the larynx and hypopharynx. Against the background of a high level of PPM1B expression, a significantly high level of profilin expression was noted. Metastasis correlated with the level of snai1 expression, while relapse after combination treatment was negatively associated with the level of vimentin expression. The obtained new data can reflect molecular peculiarities of the tumor growth in squamous cell carcinoma of the larynx and hypopharynx.
我们分析了编码参与细胞骨架重塑的蛋白质的基因的表达（RND3、SNAI1、波形蛋白、原肌球蛋白、环腺苷酸酶相关蛋白 1、埃兹蛋白和丝氨酸羟脯氨酸二肽酶 1），其依据是喉和下咽鳞状细胞癌中蛋白磷酸酶 1B（PPM1B）mRNA 的表达水平。在 PPM1B 表达水平较高的背景下，发现了明显高水平的丝氨酸羟脯氨酸二肽酶 1 表达。转移与 snai1 表达水平相关，而联合治疗后的复发与波形蛋白表达水平呈负相关。获得的新数据可以反映喉和下咽鳞状细胞癌中肿瘤生长的分子特征。
