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1
Divergent Synthesis of Natural Derivatives of (+)-Saxitoxin Including 11-Saxitoxinethanoic Acid.
Angew Chem Int Ed Engl. 2019 Feb 4;58(6):1689-1693. doi: 10.1002/anie.201811717. Epub 2019 Jan 2.
2
A Direct C11 Alkylation Strategy on the Saxitoxin Core: A Synthesis of (+)-11-Saxitoxinethanoic Acid.
Org Lett. 2019 Oct 4;21(19):7999-8002. doi: 10.1021/acs.orglett.9b02986. Epub 2019 Sep 25.
3
Synthesis of the Paralytic Shellfish Poisons (+)-Gonyautoxin 2, (+)-Gonyautoxin 3, and (+)-11,11-Dihydroxysaxitoxin.
J Am Chem Soc. 2016 May 11;138(18):5994-6001. doi: 10.1021/jacs.6b02343. Epub 2016 May 3.
4
Saxitoxin.
Angew Chem Int Ed Engl. 2014 Jun 2;53(23):5760-84. doi: 10.1002/anie.201308235. Epub 2014 Apr 25.
6
Total Synthesis of 11-Saxitoxinethanoic Acid and Evaluation of its Inhibitory Activity on Voltage-Gated Sodium Channels.
Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11600-3. doi: 10.1002/anie.201604155. Epub 2016 Aug 11.
8
Total synthesis of (+)-decarbamoylsaxitoxin and (+)-gonyautoxin 3.
Org Lett. 2010 May 7;12(9):2150-3. doi: 10.1021/ol1006696.
9
Silylpyrrole Oxidation En Route to Saxitoxin Congeners Including 11-Saxitoxinethanoic Acid.
J Org Chem. 2021 Dec 17;86(24):17790-17803. doi: 10.1021/acs.joc.1c02116. Epub 2021 Dec 7.
10
A synthesis of (+)-saxitoxin.
J Am Chem Soc. 2006 Mar 29;128(12):3926-7. doi: 10.1021/ja0608545.

引用本文的文献

1
Dearomative Mislow-Braverman-Evans Rearrangement of Aryl Sulfoxides.
JACS Au. 2025 Feb 5;5(2):998-1006. doi: 10.1021/jacsau.4c01238. eCollection 2025 Feb 24.
2
Synthesis of Saxitoxin Biosynthetic Intermediates: Reveal the Mechanism for Formation of its Tricyclic Skeleton in Biosynthesis.
Chem Asian J. 2024 Dec 16;19(24):e202400834. doi: 10.1002/asia.202400834. Epub 2024 Oct 31.
4
Discovery of Selective Inhibitors of Na1.7 Templated on Saxitoxin as Therapeutics for Pain.
ACS Med Chem Lett. 2022 Oct 18;13(11):1763-1768. doi: 10.1021/acsmedchemlett.2c00378. eCollection 2022 Nov 10.
5
Silylpyrrole Oxidation En Route to Saxitoxin Congeners Including 11-Saxitoxinethanoic Acid.
J Org Chem. 2021 Dec 17;86(24):17790-17803. doi: 10.1021/acs.joc.1c02116. Epub 2021 Dec 7.
9
Biosynthesis of Saxitoxin in Marine Dinoflagellates: An Omics Perspective.
Mar Drugs. 2020 Feb 5;18(2):103. doi: 10.3390/md18020103.
10

本文引用的文献

1
A Synthetic Strategy for Saxitoxin Skeleton by a Cascade Bromocyclization: Total Synthesis of (+)-Decarbamoyl-α-saxitoxinol.
Org Lett. 2016 Dec 16;18(24):6368-6371. doi: 10.1021/acs.orglett.6b03262. Epub 2016 Dec 5.
2
Total Synthesis of 11-Saxitoxinethanoic Acid and Evaluation of its Inhibitory Activity on Voltage-Gated Sodium Channels.
Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11600-3. doi: 10.1002/anie.201604155. Epub 2016 Aug 11.
3
Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNaV1.7.
Proc Natl Acad Sci U S A. 2016 May 24;113(21):5856-61. doi: 10.1073/pnas.1603486113. Epub 2016 May 9.
4
Synthesis of the Paralytic Shellfish Poisons (+)-Gonyautoxin 2, (+)-Gonyautoxin 3, and (+)-11,11-Dihydroxysaxitoxin.
J Am Chem Soc. 2016 May 11;138(18):5994-6001. doi: 10.1021/jacs.6b02343. Epub 2016 May 3.
5
Saxitoxin.
Angew Chem Int Ed Engl. 2014 Jun 2;53(23):5760-84. doi: 10.1002/anie.201308235. Epub 2014 Apr 25.
7
A stereocontrolled synthesis of (+)-saxitoxin.
J Am Chem Soc. 2011 Dec 21;133(50):20172-4. doi: 10.1021/ja2098063. Epub 2011 Nov 23.
8
Diastereoselective total synthesis of (±)-schindilactone A.
Angew Chem Int Ed Engl. 2011 Aug 1;50(32):7373-7. doi: 10.1002/anie.201103088. Epub 2011 Jul 7.
9
Neurotoxic alkaloids: saxitoxin and its analogs.
Mar Drugs. 2010 Jul 20;8(7):2185-211. doi: 10.3390/md8072185.
10
Total synthesis of (+)-decarbamoylsaxitoxin and (+)-gonyautoxin 3.
Org Lett. 2010 May 7;12(9):2150-3. doi: 10.1021/ol1006696.

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