Cooper University Hospital, Camden, New Jersey.
Hovnanian Children's Hospital at Hackensack Meridian Health, Hackensack, New Jersey.
Pharmacotherapy. 2019 Jan;39(1):109-113. doi: 10.1002/phar.2198. Epub 2018 Dec 11.
Levetiracetam (LEV) is a pyrrolidine derivative antiepileptic medication used for the treatment of seizures in pediatric and adult patients. We report a case of probable LEV-induced aseptic meningitis in a 13-year-old girl. The patient received LEV for a generalized seizure disorder and presented with symptoms 5 days after medication initiation. Ten days after LEV initiation, the patient presented to the hospital for further management. During her hospital course, infectious etiologies were ruled out with clinical and diagnostic testing. Upon discontinuation of LEV, the patient's symptoms resolved. Although select antiepileptic medications have been associated with drug-induced aseptic meningitis (DIAM), to date, no reports have been published about DIAM following the administration of LEV. We describe and categorize the probability of DIAM in association with LEV, as observed in a patient case.
左乙拉西坦（LEV）是一种吡咯烷衍生物类抗癫痫药物，用于治疗儿科和成年患者的癫痫发作。我们报告了一例 13 岁女孩可能由 LEV 引起的无菌性脑膜炎病例。该患者因全身性癫痫发作接受 LEV 治疗，在用药 5 天后出现症状。在开始使用 LEV 后 10 天，患者因进一步治疗而到医院就诊。在她的住院期间，通过临床和诊断测试排除了感染性病因。停用 LEV 后，患者的症状得到缓解。尽管一些抗癫痫药物与药物诱导的无菌性脑膜炎（DIAM）有关，但迄今为止，尚无关于 LEV 给药后发生 DIAM 的报告。我们描述并分类了与 LEV 相关的 DIAM 的可能性，如在患者病例中观察到的那样。
