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全关节置换术后的阿片类药物处方

Opioid Prescriptions After Total Joint Arthroplasty.

作者信息

Sibia Udai S, Mandelblatt Abigail E, Caleb Alexander G, King Paul J, MacDonald James H

机构信息

The Center for Joint Replacement, Anne Arundel Medical Center, Annapolis, Maryland.

Center for Drug Safety and Effectiveness, Johns Hopkins University; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health; Division of General Internal Medicine, Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland.

出版信息

J Surg Orthop Adv. 2018 Fall;27(3):231-236.

Abstract

Prescription opioids are commonly prescribed for pain relief after total joint arthroplasty (TJA), yet little is known about the quantity of opioids prescribed after surgery. This study retrospectively reviewed a consecutive series of 1000 TJAs from April 2014 through September 2015. Postoperative opioid prescriptions were quantified using standardized morphine milligram equivalents (MME). Eighty-four percent of total knee arthroplasty (TKA) and 77% of total hip arthroplasty (THA) patients were opioid naïve. The median opioid volume of the first prescription for those undergoing TKA was greater than for those undergoing THA (600 vs. 450 MME), as was the proportion of individuals requiring one or more refills (48% vs. 32%). The total volume of opioids after TKA was also higher than for total hip replacement (870 vs. 525 MME). Patients who were not opioid naïve were prescribed substantially more opioids than their counterparts after TKA (mean 1593 vs. 1064 MME, < .001) and THA (mean 1031 vs. 663 MME, < .001). Decreasing opioid use before surgery may decrease total volume of opioid prescriptions after TJA. (Journal of Surgical Orthopaedic Advances 27(3):231-236, 2018).

摘要

处方阿片类药物常用于全关节置换术(TJA)后的疼痛缓解,但术后阿片类药物的处方量却鲜为人知。本研究回顾性分析了2014年4月至2015年9月期间连续的1000例TJA病例。术后阿片类药物处方量采用标准化吗啡毫克当量(MME)进行量化。84%的全膝关节置换术(TKA)患者和77%的全髋关节置换术(THA)患者术前未使用过阿片类药物。接受TKA的患者首次处方的阿片类药物中位数剂量高于接受THA的患者(600 vs. 450 MME),需要一次或多次补充处方的患者比例也是如此(48% vs. 32%)。TKA术后阿片类药物的总量也高于全髋关节置换术(870 vs. 525 MME)。术前未使用过阿片类药物的患者在TKA术后(平均1593 vs. 1064 MME,<0.001)和THA术后(平均1031 vs. 663 MME,<0.001)所开具的阿片类药物量明显多于其对应的患者。术前减少阿片类药物的使用可能会降低TJA术后阿片类药物的处方总量。(《外科骨科进展杂志》27(3):231 - 236, 2018)

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